IRE1-1 inositol requiring 1-1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IRE1-1
Official Full Name: inositol requiring 1-1
Primary source: TAIR:AT5G24360
Locus tag: AT5G24360
See related: Araport:AT5G24360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA INOSITOL REQUIRING 1-1; ATIRE1-1; AtIRE1b; inositol requiring 1-1; IRE1B; K16H17.7; K16H17_7
Summary: IRE1A and IRE1B catalyze bZIP60 mRNA splicing, producing the active bZIP60 transcription factor.
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Genomic context

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See IRE1-1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (8316388..8319981)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found the triple mutant of IRE1A, IRE1B, and IRE1C is lethal. Mutant IRE1B lacking the sensor domain is not responsible for the unfolded protein response signal transduction.
Title: Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis.
IRE1B is posited to be a 'licensing factor' linking endoplasmic reticulum stress to autophagy.
Title: IRE1B degrades RNAs encoding proteins that interfere with the induction of autophagy by ER stress in Arabidopsis thaliana.
These data suggest that ER stress-activated pathways, led by IRE1 and BI-1, respond to invading potyvirus and potexviruses to restrict virus infection and enable physiological changes enabling plants to tolerate virus assault.
Title: The IRE1/bZIP60 Pathway and Bax Inhibitor 1 Suppress Systemic Accumulation of Potyviruses and Potexviruses in Arabidopsis and Nicotiana benthamiana Plants.
An Arabidopsis mutant of a conserved endoplasmic reticulum (ER) stress sensor IRE1 exhibits defects in the auxin response and levels, which supports that the plant IRE1 is required for auxin homeostasis.
Title: Inter-regulation of the unfolded protein response and auxin signaling.
Arabidopsis AGB1, a subunit of the ubiquitous heterotrimeric GTP-binding protein family, and AtIRE1A/AtIRE1B independently control two essential plant unfolded protein response pathways.
Title: AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.
Both IRE1a and IRE1b are transcriptionally induced during chemically-induced endoplasmic reticulum stress, bacterial pathogen infection and treatment with the immune signal salicylic acid. [IRE1b]
Title: IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses.
an ER stress sensor, INOSITOL-REQUIRING ENZYME-1b (IRE1b), was found to be required for ER stress-induced autophagy.
Title: Degradation of the endoplasmic reticulum by autophagy during endoplasmic reticulum stress in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203454.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within RNA splicing, via endonucleolytic cleavage and ligation	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of autophagy in response to ER overload	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy in response to ER overload	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salicylic acid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol requiring 1-1

NP_001190382.1

inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1).

NP_001190383.1

inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1).

NP_568444.1

inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyrrolo-quinoline quinone beta-propeller repeat (InterPro:IPR018391), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8316388..8319981

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122344.5 → NP_568444.1 inositol requiring 1-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568444.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93VJ2, Q94IG5, Q9FIN6

UniProtKB/TrEMBL

A0A178UD27, A0A5S9Y779

Conserved Domains (4) summary

cd09213
Location:48 → 392

Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

cd10422
Location:749 → 875

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:463 → 744

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:457 → 745

PKc_like; Protein Kinases, catalytic domain
NM_001203453.2 → NP_001190382.1 inositol requiring 1-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190382.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UD27, A0A5S9Y779, F4KH40

Conserved Domains (4) summary

cd09213
Location:54 → 398

Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

cd10422
Location:755 → 881

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:469 → 750

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:463 → 751

PKc_like; Protein Kinases, catalytic domain
NM_001203454.1 → NP_001190383.1 inositol requiring 1-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190383.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UD27, A0A5S9Y779, A0A654G3Y0, F4KH41

Conserved Domains (4) summary

cd09213
Location:34 → 378

Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

cd10422
Location:735 → 861

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:449 → 730

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:443 → 731

PKc_like; Protein Kinases, catalytic domain