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    RAN1 copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834509, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAN1
    Official Full Name
    copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1)
    Primary source
    TAIR:AT5G44790
    Locus tag
    AT5G44790
    See related
    Araport:AT5G44790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HMA7; K23L20.14; K23L20_14; RESPONSIVE-TO-ANTAGONIST 1
    Summary
    ATP dependent copper transporter vital for ethylene response pathway
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    Genomic context

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    See RAN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (18075562..18080160, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene high molecular weight subunit-like glutenin Neighboring gene organellar single-stranded DNA binding protein 3 Neighboring gene chromatin remodeling 4 Neighboring gene Nucleotide-diphospho-sugar transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of a small GTP-binding protein Ran1 in Arabidopsis leads to promoted elongation growth and enhanced disease resistance against P. syringae DC3000. Xu P, et al. Plant J, 2021 Nov. PMID 34312926
    2. Arabidopsis RAN1 mediates seed development through its parental ratio by affecting the onset of endosperm cellularization. Liu P, et al. Mol Plant, 2014 Aug. PMID 24719465
    3. RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis. Hirayama T, et al. Cell, 1999 Apr 30. PMID 10319818
    4. Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1. Li W, et al. PLoS Genet, 2017 Apr. PMID 28388654, Free PMC Article
    5. Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains. Zimmermann M, et al. Biochemistry, 2009 Dec 15. PMID 19883117

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of a small GTP-binding protein Ran1 in Arabidopsis leads to promoted elongation growth and enhanced disease resistance against P. syringae DC3000.
      Title: Overexpression of a small GTP-binding protein Ran1 in Arabidopsis leads to promoted elongation growth and enhanced disease resistance against P. syringae DC3000.
    2. Our study provided genetic evidence for the first time that, copper ions necessary for ethylene receptor biogenesis and signaling are transported from ATX1 to RAN1.
      Title: Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1.
    3. parental ratio of RAN1 regulates the onset of endosperm cellularization through its genetic interaction with MINI3
      Title: Arabidopsis RAN1 mediates seed development through its parental ratio by affecting the onset of endosperm cellularization.
    4. Chimeric HMA7 binds copper with an affinity between those of HMA4 and HMA7 but binds zinc more weakly than either parent protein does.
      Title: Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123847.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables P-type monovalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1)
    NP_199292.1
    • RESPONSIVE-TO-ANTAGONIST 1 (RAN1); CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Heavy-metal-associated, conserved site (InterPro:IPR017969), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), Copper ion-binding (InterPro:IPR006122), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: heavy metal atpase 5 (TAIR:AT1G63440.1); Has 47831 Blast hits to 34622 proteins in 3461 species: Archae - 1084; Bacteria - 31583; Metazoa - 5562; Fungi - 2713; Plants - 1975; Viruses - 3; Other Eukaryotes - 4911 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18075562..18080160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123847.3 → NP_199292.1  copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199292.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7J8
      UniProtKB/TrEMBL
      Q94KD6
      Conserved Domains (4) summary
      COG4087
      Location:786 → 927
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:62 → 122
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      TIGR01511
      Location:351 → 966
      ATPase-IB1_Cu; copper-(or silver)-translocating P-type ATPase
      pfam00122
      Location:407 → 647
      E1-E2_ATPase; E1-E2 ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7J8.1

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