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    MAD1 mitotic checkpoint family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835051, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAD1
    Official Full Name
    mitotic checkpoint family protein
    Primary source
    TAIR:AT5G49880
    Locus tag
    AT5G49880
    See related
    Araport:AT5G49880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMAD1; K9P8.2; K9P8_2; mitotic arrest deficient 1; NES1; NITRIC OXIDE-INDUCED EARLY COTYLEDON SENESCENCE 1
    Summary
    Encodes a spindle assembly checkpoint protein MAD1.
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    Genomic context

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    See MAD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (20282111..20288084)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chloride channel C Neighboring gene Beta-glucosidase, GBA2 type family protein Neighboring gene chloroplast heat shock protein 70-2 Neighboring gene Octicosapeptide/Phox/Bem1p family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis. Du J, et al. J Exp Bot, 2014 Jul. PMID 24336389, Free PMC Article
    2. Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA. Ding D, et al. Plant Mol Biol, 2012 Jun. PMID 22457071
    3. Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1. Bao Z, et al. Nat Commun, 2014 Nov 28. PMID 25429892
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ore1 loss-of-function mutants were epistatic to nes1, suggesting the dominant role of ORE1 and the antagonistic role of NES1 during nitric oxide-induced cotyledon senescence in Arabidopsis.
      Title: Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis.
    2. Data suggest that NUA scaffolds AtMAD1 and AtMAD2 at the nuclear pore to form a functional complex and that both NUA and AtMAD2 suppress premature exit from cell division at the Arabidopsis root meristem.
      Title: Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_124366.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mitotic checkpoint family protein
    NP_199799.1
    • mitotic checkpoint family protein; CONTAINS InterPro DOMAIN/s: Mitotic checkpoint (InterPro:IPR008672); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20282111..20288084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124366.4 → NP_199799.1  mitotic checkpoint family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199799.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTY1
      UniProtKB/TrEMBL
      A0A178UP86, A0A5S9YCL3
      Conserved Domains (1) summary
      pfam05557
      Location:113 → 724
      MAD; Mitotic checkpoint protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTY1.1

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