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    BETA-UP beta-ureidopropionase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836558, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BETA-UP
    Official Full Name
    beta-ureidopropionase
    Primary source
    TAIR:AT5G64370
    Locus tag
    AT5G64370
    See related
    Araport:AT5G64370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    beta-ureidopropionase; MSJ1.21; MSJ1_21; PYD3; PYRIMIDINE 3
    Summary
    PYD3 encodes a beta-ureidopropionase which, when expressed in E. coli, has been shown to convert beta-ureidopropionate into beta-alanine. It localizes to the cytosol and plays an important role in uracil degradation.
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    Genomic context

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    See BETA-UP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (25739131..25741222)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FK506-binding protein 12 Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene Inositol monophosphatase family protein Neighboring gene RNA-binding KH domain-containing protein Neighboring gene CHCH domain protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of plant beta-ureidopropionase and functional overexpression in Escherichia coli. Walsh TA, et al. Plant Physiol, 2001 Feb. PMID 11161056, Free PMC Article
    2. A functional analysis of the pyrimidine catabolic pathway in Arabidopsis. Zrenner R, et al. New Phytol, 2009. PMID 19413687, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125833.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-ureidopropionase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in beta-alanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to nitrogen levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within uracil catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-ureidopropionase
    NP_201242.2
    • beta-ureidopropionase (BETA-UP); FUNCTIONS IN: beta-ureidopropionase activity; INVOLVED IN: nitrogen compound metabolic process, uracil catabolic process, cellular response to nitrogen levels; LOCATED IN: cytosol; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase (InterPro:IPR003010); BEST Arabidopsis thaliana protein match is: nitrilase-like protein 1 (TAIR:AT2G27450.2); Has 6588 Blast hits to 6556 proteins in 1697 species: Archae - 146; Bacteria - 4263; Metazoa - 430; Fungi - 262; Plants - 305; Viruses - 11; Other Eukaryotes - 1171 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25739131..25741222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125833.5 → NP_201242.2  beta-ureidopropionase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201242.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H183, Q9FMF2
      UniProtKB/TrEMBL
      A0A178UGH6, A0A5S9YGX4, A0A654GF10
      Conserved Domains (1) summary
      PLN00202
      Location:4 → 408
      PLN00202; beta-ureidopropionase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H183.1

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