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    ZWI kinesin-like calmodulin-binding protein (ZWICHEL) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836723, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZWI
    Official Full Name
    kinesin-like calmodulin-binding protein (ZWICHEL)
    Primary source
    TAIR:AT5G65930
    Locus tag
    AT5G65930
    See related
    Araport:AT5G65930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K14B20.10; K14B20_10; KCBP; KINESIN-LIKE CALMODULIN-BINDING PROTEIN; PKCBP; POTATO KINESIN-LIKE CALMODULIN-BINDING PROTEIN; ZWICHEL
    Summary
    encodes a novel member of the kinesin superfamily of motor proteins. recessive mutations have reduced number of trichome branches.
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    Genomic context

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    See ZWI in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (26369857..26376572, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene beta-hydroxyisobutyryl-CoA hydrolase 1 Neighboring gene miscRNA Neighboring gene trafficking protein particle complex subunit-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Moss Kinesin-14 KCBP Accelerates Chromatid Motility in Anaphase. Yoshida MW, et al. Cell Struct Funct, 2019. PMID 31548446
    2. Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin. Tian J, et al. Elife, 2015 Aug 19. PMID 26287478, Free PMC Article
    3. A novel plant calmodulin-binding protein with a kinesin heavy chain motor domain. Reddy AS, et al. J Biol Chem, 1996 Mar 22. PMID 8636137
    4. In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis. Song H, et al. Proc Natl Acad Sci U S A, 1997 Jan 7. PMID 8990207, Free PMC Article
    5. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. Vinogradova MV, et al. PLoS One, 2013. PMID 23805258, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that KCBP binds to non-membranous naked chromosomes via an unidentified protein(s) for their transport.
      Title: Moss Kinesin-14 KCBP Accelerates Chromatid Motility in Anaphase.
    2. our findings define a novel genetic and molecular mechanism by which TCS1 interacts with KCBP to regulate trichome cell shape by influencing the stability of microtubules.
      Title: TCS1, a Microtubule-Binding Protein, Interacts with KCBP/ZWICHEL to Regulate Trichome Cell Shape in Arabidopsis thaliana.
    3. The MyTH4 domain and the FERM domain in the N-terminal tail of KCBP physically bind to microtubules and F-actin, respectively.
      Title: Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203699.1
    NM_125990.4
    NM_180945.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables minus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical microtubule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trichome patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like calmodulin-binding protein (ZWICHEL)
    NP_001190628.1
    • ZWICHEL (ZWI); CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), Band 4.1 domain (InterPro:IPR019749), FERM, N-terminal (InterPro:IPR018979), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.2).
    NP_569022.2
    • ZWICHEL (ZWI); FUNCTIONS IN: microtubule motor activity, calmodulin binding; INVOLVED IN: trichome branching, pollen germination; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), FERM, N-terminal (InterPro:IPR018979), Band 4.1 domain (InterPro:IPR019749), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.1); Has 92267 Blast hits to 53660 proteins in 2386 species: Archae - 1115; Bacteria - 10663; Metazoa - 44616; Fungi - 7060; Plants - 5081; Viruses - 192; Other Eukaryotes - 23540 (source: NCBI BLink).
    NP_851276.1
    • ZWICHEL (ZWI); FUNCTIONS IN: microtubule motor activity, calmodulin binding; INVOLVED IN: trichome branching, pollen germination; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), FERM, N-terminal (InterPro:IPR018979), Band 4.1 domain (InterPro:IPR019749), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.1); Has 92234 Blast hits to 53602 proteins in 2354 species: Archae - 1118; Bacteria - 10667; Metazoa - 44581; Fungi - 7061; Plants - 5079; Viruses - 192; Other Eukaryotes - 23536 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26369857..26376572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125990.4 → NP_569022.2  kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_569022.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22326, O23102, Q0WM77, Q39130, Q8VZV4, Q9FHN8
      UniProtKB/TrEMBL
      A0A178UBS0, A0A5S9YHC7, A0A654GET6
      Conserved Domains (5) summary
      smart00139
      Location:115 → 274
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:283 → 499
      B41; Band 4.1 homologues
      COG1196
      Location:620 → 890
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13200
      Location:496 → 602
      FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein
      cd01366
      Location:886 → 1211
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. NM_180945.2 → NP_851276.1  kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GET6
      Conserved Domains (8) summary
      smart00129
      Location:888 → 1215
      KISc; Kinesin motor, catalytic domain. ATPase
      smart00139
      Location:115 → 274
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:283 → 498
      B41; Band 4.1 homologues
      cd13200
      Location:495 → 601
      FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein
      cd01366
      Location:885 → 1210
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00373
      Location:395 → 499
      FERM_M; FERM central domain
      pfam09379
      Location:283 → 356
      FERM_N; FERM N-terminal domain
      pfam16796
      Location:869 → 894
      Microtub_bd; Microtubule binding

    3. NM_001203699.1 → NP_001190628.1  kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GET6, F4JXM5
      Conserved Domains (8) summary
      smart00129
      Location:895 → 1222
      KISc; Kinesin motor, catalytic domain. ATPase
      smart00139
      Location:121 → 280
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:289 → 505
      B41; Band 4.1 homologues
      cd13200
      Location:502 → 608
      FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein
      cd01366
      Location:892 → 1217
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00373
      Location:402 → 506
      FERM_M; FERM central domain
      pfam09379
      Location:289 → 363
      FERM_N; FERM N-terminal domain
      pfam16796
      Location:876 → 901
      Microtub_bd; Microtubule binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FHN8.1

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