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    SOS2 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833502, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SOS2
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT5G35410
    Locus tag
    AT5G35410
    See related
    Araport:AT5G35410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSOS2; CBL-INTERACTING PROTEIN KINASE 24; CIPK24; K21B8.3; K21B8_3; SALT OVERLY SENSITIVE 2; SNF1-RELATED PROTEIN KINASE 3.11; SNRK3.11
    Summary
    encodes a member of the CBL-interacting protein kinase family, is a regulatory component controlling plant potassium nutrition
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    Genomic context

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    See SOS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (13634399..13638375)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition. Zhu JK, et al. Plant Cell, 1998 Jul. PMID 9668136, Free PMC Article
    2. Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress. Li J, et al. EMBO J, 2023 Apr 17. PMID 36811145, Free PMC Article
    3. The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance. Liu J, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10725382, Free PMC Article
    4. SOS2-AFP2 module regulates seed germination by inducing ABI5 degradation in response to salt stress in Arabidopsis. Wang C, et al. Biochem Biophys Res Commun, 2024 Sep 3. PMID 38838447
    5. The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3. Halfter U, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10725350, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress.
      Title: Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress.
    2. SOS2-AFP2 module regulates seed germination by inducing ABI5 degradation in response to salt stress in Arabidopsis.
      Title: SOS2-AFP2 module regulates seed germination by inducing ABI5 degradation in response to salt stress in Arabidopsis.
    3. The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
      Title: The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
    4. Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress.
      Title: Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress.
    5. The plasma-membrane polyamine transporter PUT3 is regulated by the Na(+) /H(+) antiporter SOS1 and protein kinase SOS2.
      Title: The plasma-membrane polyamine transporter PUT3 is regulated by the Na(+) /H(+) antiporter SOS1 and protein kinase SOS2.
    6. SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2.
      Title: Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.
    7. EIN3-SOS2 might link the ethylene signaling pathway and the SOS pathway in Arabidopsis salt responses.
      Title: EIN3 and SOS2 synergistically modulate plant salt tolerance.
    8. crystal structures of CIPK23 and CIPK24/SOS2; CIPK23 is intrinsically inactive and requires an external stimulation, CIPK24/SOS2 displays basal activity
      Title: Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.
    9. The GI-SOS2 interaction introduces a higher order regulatory circuit that can explain in molecular terms, the long observed connection between floral transition and adaptive environmental stress tolerance in Arabidopsis.
      Title: Release of SOS2 kinase from sequestration with GIGANTEA determines salt tolerance in Arabidopsis.
    10. The tonoplast-localized CBL2 is critical for plant development and ion homeostasis in plant cells, at least in part through regulation of vacuolar H+-ATPase activity in plants.
      Title: Tonoplast calcium sensors CBL2 and CBL3 control plant growth and ion homeostasis through regulating V-ATPase activity in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344103.1
    NM_122932.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_198391.1
    • SALT OVERLY SENSITIVE 2 (SOS2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 8 (TAIR:AT4G24400.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13634399..13638375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122932.5 → NP_198391.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LDI3, Q9LKR2
      UniProtKB/TrEMBL
      A0A178UB05, A0A384KKJ4, M5BEH1, M5BFD1
      Conserved Domains (2) summary
      cd12195
      Location:311 → 426
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      cl21453
      Location:10 → 263
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001344103.1 → NP_001332317.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGJ7, M5BFD1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LDI3.1

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