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    GMII golgi alpha-mannosidase II [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831347, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GMII
    Official Full Name
    golgi alpha-mannosidase II
    Primary source
    TAIR:AT5G14950
    Locus tag
    AT5G14950
    See related
    Araport:AT5G14950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGMII; F2G14.70; F2G14_70; golgi alpha-mannosidase II
    Summary
    Encodes a golgi alpha-mannosidase, an enzyme responsible for the formation of major complex-type N-glycans.
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    Genomic context

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    See GMII in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (4837071..4842067, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene senescence-associated gene 101 Neighboring gene Major facilitator superfamily protein Neighboring gene DP-E2F-like 2 Neighboring gene seed maturation-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of Arabidopsis thaliana Golgi alpha-mannosidase II, a key enzyme in the formation of complex N-glycans in plants. Strasser R, et al. Plant J, 2006 Mar. PMID 16460512
    2. Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus. Kang JS, et al. Proc Natl Acad Sci U S A, 2008 Apr 15. PMID 18408158, Free PMC Article
    3. Time-resolved fluorescence imaging reveals differential interactions of N-glycan processing enzymes across the Golgi stack in planta. Schoberer J, et al. Plant Physiol, 2013 Apr. PMID 23400704, Free PMC Article
    4. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121499.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi cis cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    golgi alpha-mannosidase II
    NP_196999.1
    • golgi alpha-mannosidase II (GMII); CONTAINS InterPro DOMAIN/s: Glycoside hydrolase-type carbohydrate-binding (InterPro:IPR011013), Glycoside hydrolase/deacetylase, beta/alpha-barrel (InterPro:IPR011330), Glycoside hydrolase, family 38, central domain (InterPro:IPR015341), Glycoside hydrolase, family 38, core (InterPro:IPR000602), Glycosyl hydrolases 38, C-terminal (InterPro:IPR011682); BEST Arabidopsis thaliana protein match is: Glycosyl hydrolase family 38 protein (TAIR:AT5G66150.1); Has 2033 Blast hits to 1987 proteins in 497 species: Archae - 20; Bacteria - 870; Metazoa - 708; Fungi - 131; Plants - 147; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4837071..4842067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121499.3 → NP_196999.1  golgi alpha-mannosidase II [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940T6, Q9LFR0
      UniProtKB/TrEMBL
      A0A5S9Y480
      Conserved Domains (4) summary
      PLN02701
      Location:114 → 1170
      PLN02701; alpha-mannosidase
      cd10809
      Location:152 → 504
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:499 → 583
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:755 → 1165
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFR0.1

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