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    RHF2A RING-H2 group F2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832260, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RHF2A
    Official Full Name
    RING-H2 group F2A
    Primary source
    TAIR:AT5G22000
    Locus tag
    AT5G22000
    See related
    Araport:AT5G22000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    RING-H2 FINGER PROTEIN RHF2A; RING-H2 group F2A
    Summary
    encodes a RING-type E3 ubiquitin ligase implicated in gametogenesis. Double mutant analyses with RHF1a suggests that RHF2a may be involved in targetting ICK4KRP6 for degradation following meiosis in order to allow the mitoses associated with megagametogenesis and microgametogenesis to occur. RHF2a is expressed in all four floral whorls and is present at ~8-fold higher levels than RHF1a in inflorescences by RT-PCR analyses.
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    Genomic context

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    See RHF2A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (7277182..7280344)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene replication factor C1 Neighboring gene Calcium-dependent phosphotriesterase superfamily protein Neighboring gene ubiquitin-specific protease 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. Liu J, et al. Plant Cell, 2008 Jun. PMID 18552199, Free PMC Article
    2. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343714.1
    NM_122125.3
    NM_180719.4
    NM_180720.1

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within megagametogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within microgametogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING-H2 group F2A
    NP_568410.1
    • RING-H2 group F2A (RHF2A); FUNCTIONS IN: zinc ion binding; INVOLVED IN: regulation of cell cycle, proteolysis involved in cellular protein catabolic process, megagametogenesis, microgametogenesis; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 group F1A (TAIR:AT4G14220.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851050.1
    • RING-H2 group F2A (RHF2A); FUNCTIONS IN: zinc ion binding; INVOLVED IN: regulation of cell cycle, proteolysis involved in cellular protein catabolic process, megagametogenesis, microgametogenesis; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 group F1A (TAIR:AT4G14220.1); Has 8011 Blast hits to 5867 proteins in 317 species: Archae - 0; Bacteria - 141; Metazoa - 1822; Fungi - 396; Plants - 2620; Viruses - 42; Other Eukaryotes - 2990 (source: NCBI BLink).
    NP_851051.1
    • RING-H2 group F2A (RHF2A); FUNCTIONS IN: zinc ion binding; INVOLVED IN: regulation of cell cycle, proteolysis involved in cellular protein catabolic process, megagametogenesis, microgametogenesis; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 group F1A (TAIR:AT4G14220.1); Has 8047 Blast hits to 5903 proteins in 316 species: Archae - 0; Bacteria - 141; Metazoa - 1863; Fungi - 401; Plants - 2610; Viruses - 42; Other Eukaryotes - 2990 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7277182..7280344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180719.4 → NP_851050.1  RING-H2 group F2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN0, Q3E981, Q8GXA8, Q9ZT42
      UniProtKB/TrEMBL
      A0A178UA98, A0A5S9Y8E4
      Conserved Domains (2) summary
      cd00162
      Location:33 → 73
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:33 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_122125.3 → NP_568410.1  RING-H2 group F2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFN0, Q3E981, Q8GXA8, Q9ZT42
      UniProtKB/TrEMBL
      A0A178UA98, A0A5S9Y8E4
      Conserved Domains (2) summary
      cd00162
      Location:33 → 73
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:33 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_180720.1 → NP_851051.1  RING-H2 group F2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZT42
      Conserved Domains (2) summary
      pfam12678
      Location:27 → 73
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:33 → 73
      zf-RING_2; Ring finger domain

    4. NM_001343714.1 → NP_001331677.1  RING-H2 group F2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEK7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZT42.1

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