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    ACA4 autoinhibited Ca(2+)-ATPase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818754, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACA4
    Official Full Name
    autoinhibited Ca(2+)-ATPase
    Primary source
    TAIR:AT2G41560
    Locus tag
    AT2G41560
    See related
    Araport:AT2G41560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''autoinhibited Ca(2+)-ATPase; autoinhibited Ca(2+)-ATPase; isoform 4; isoform 4''; T32G6.8; T32G6_8
    Summary
    Encodes a calmodulin-regulated Ca(2+)-ATPase that improves salt tolerance in yeast. Localized to the vacuole. Lesion mimic phenotype when mutation in the gene is combined with a mutation in ACA11. Lesion mimic phenotype of double knockout can be suppressed by nutritional supplements that increase anion levels (e.g. 15 mM Nitrate, Chloride, or Phosphate).
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    Genomic context

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    See ACA4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (17332050..17337492, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase Neighboring gene 6-phosphogluconate dehydrogenase family protein Neighboring gene Rho termination factor Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway. Boursiac Y, et al. Plant Physiol, 2010 Nov. PMID 20837703, Free PMC Article
    2. Resting cytosol Ca2+ level maintained by Ca2+ pumps affects environmental responses in Arabidopsis. Li Z, et al. Plant Physiol, 2023 Apr 3. PMID 36715402, Free PMC Article
    3. The ACA4 gene of Arabidopsis encodes a vacuolar membrane calcium pump that improves salt tolerance in yeast. Geisler M, et al. Plant Physiol, 2000 Dec. PMID 11115896, Free PMC Article
    4. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
    5. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy VS, et al. J Biol Chem, 2002 Mar 22. PMID 11782485

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A double disruption of Arabidopsis vacuolar pumps ACA4 and ACA11 results in a high frequency of apoptosis-like lesions.
      Title: Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336925.1
    NM_001336926.1
    NM_001336927.1
    NM_129719.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    acts_upstream_of_or_within response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane HDA PubMed 
    located_in vacuole HDA PubMed 
    located_in vacuole TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    autoinhibited Ca(2+)-ATPase
    NP_181687.1
    • ''autoinhibited Ca(2+)-ATPase, isoform 4'' (ACA4); FUNCTIONS IN: calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: in 6 processes; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: autoinhibited Ca2+-ATPase 11 (TAIR:AT3G57330.1); Has 45699 Blast hits to 34603 proteins in 3211 species: Archae - 845; Bacteria - 31242; Metazoa - 4073; Fungi - 2705; Plants - 2048; Viruses - 3; Other Eukaryotes - 4783 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17332050..17337492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129719.4 → NP_181687.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22218
      UniProtKB/TrEMBL
      A0A5S9X635
      Conserved Domains (2) summary
      TIGR01517
      Location:57 → 1009
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12515
      Location:4 → 48
      CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

    2. NM_001336925.1 → NP_001323669.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VS00, A0A1P8AXT8

    3. NM_001336926.1 → NP_001323668.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VS00, A0A1P8AXT8

    4. NM_001336927.1 → NP_001323670.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VS00, A0A1P8AXT8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22218.1

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