Rtl1 retrotransposon Gaglike 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtl1provided by MGI
Official Full Name: retrotransposon Gaglike 1provided by MGI
Primary source: MGI:MGI:2656842
See related: Ensembl:ENSMUSG00000085925 AllianceGenome:MGI:2656842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mar; Mor1; Mart1; Peg11; 6430411K18Rik
Summary: Involved in several processes, including placenta development; skeletal muscle satellite cell proliferation; and skeletal muscle tissue development. Acts upstream of or within angiogenesis and labyrinthine layer development. Is active in Z disc. Is expressed in several structures, including diaphragm; genitourinary system; immune system; musculature; and neocortex layer. Orthologous to human RTL1 (retrotransposon Gag like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 60.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (109531141..109570852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (109564900..109604418, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
Title: The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes.
Title: Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes.
Paternally expressed 11/Retrotransposon-like 1 (Peg11/Rtl1) knockout (KO) mice show mid- to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality
Title: Severe damage to the placental fetal capillary network causes mid- to late fetal lethality and reduction in placental size in Peg11/Rtl1 KO mice.
miR-127 is an essential regulator of Rtl1, mediated by a trans-homologue interaction between reciprocally imprinted genes on the maternally and paternally inherited chromosomes
Title: A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development.
Rtl1, an imprinted gene with preferential expression from the paternal allele, is essential for maintenance of the fetal capillaries.
Title: Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta.
These data support a role for mir-127 and mir-136 in the epigenetic reprogramming of the Rtl1 imprinting process.
Title: Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos.
Despite the coordinate down-regulation of Dlk1 and Rtl1 mRNA levels, Rtl1 over-expression did not affect the time course of adipogenesis or Dlk1 expression
Title: Adipogenesis in mouse 3T3L1 cells: the effects of Rtl1 over-expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta development	IDA Inferred from Direct Assay more info	PubMed
involved_in placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retrotransposon-like protein 1

Names: mammalian retrotransposon derived protein 1; paternally expressed gene 11 protein; retrotransposon-derived protein PEG11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_184109.2 → NP_908998.1 retrotransposon-like protein 1

See identical proteins and their annotated locations for NP_908998.1

Status: VALIDATED

Source sequence(s)

AC152063

Consensus CDS

CCDS26170.1

UniProtKB/Swiss-Prot

Q7M732

UniProtKB/TrEMBL

B4YB44

Related

ENSMUSP00000115957.3, ENSMUST00000149046.4

Conserved Domains (5) summary

cd00303
Location:675 → 764

retropepsin_like; Retropepsins; pepsin-like aspartate proteases

pfam17919
Location:1106 → 1201

RT_RNaseH_2; RNase H-like domain found in reverse transcriptase

NF000535
Location:245 → 385

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

cl02808
Location:886 → 1043

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...

cl29674
Location:493 → 586

Retrotrans_gag; Retrotransposon gag protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

109531141..109570852 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246797.2 → XP_030102657.1 retrotransposon-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q7M732

UniProtKB/TrEMBL

B4YB44

Conserved Domains (5) summary

cd00303
Location:675 → 764

retropepsin_like; Retropepsins; pepsin-like aspartate proteases

pfam17919
Location:1106 → 1201

RT_RNaseH_2; RNase H-like domain found in reverse transcriptase

NF000535
Location:245 → 385

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

cl02808
Location:886 → 1043

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...

cl29674
Location:493 → 586

Retrotrans_gag; Retrotransposon gag protein