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    F3H flavanone 3-hydroxylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824287, updated on 18-Sep-2024

    Summary

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    Official Symbol
    F3H
    Official Full Name
    flavanone 3-hydroxylase
    Primary source
    TAIR:AT3G51240
    Locus tag
    AT3G51240
    See related
    Araport:AT3G51240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3'H; flavanone 3-hydroxylase; FLAVANONE 3-HYDROXYLASE; TRANSPARENT TESTA 6; TT6
    Summary
    Encodes flavanone 3-hydroxylase that is coordinately expressed with chalcone synthase and chalcone isomerases. Regulates flavonoid biosynthesis. Not responsive to auxin or ethylene stimulus (qRT-PCR).
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    Genomic context

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    See F3H in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (19025192..19026872)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WEB family protein (DUF827) Neighboring gene chalcone-flavanone isomerase family protein Neighboring gene ncRNA Neighboring gene Senescence/dehydration-associated protein-like protein Neighboring gene 20S proteasome alpha subunit PAD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and genetic characterization of Arabidopsis flavanone 3beta-hydroxylase. Owens DK, et al. Plant Physiol Biochem, 2008 Oct. PMID 18657430
    2. Knock-out mutants from an En-1 mutagenized Arabidopsis thaliana population generate phenylpropanoid biosynthesis phenotypes. Wisman E, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770503, Free PMC Article
    3. Analysis of flavanone 3-hydroxylase in Arabidopsis seedlings. Coordinate regulation with chalcone synthase and chalcone isomerase. Pelletier MK, et al. Plant Physiol, 1996 May. PMID 8685272, Free PMC Article
    4. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives. Schilbert HM, et al. BMC Plant Biol, 2024 Feb 9. PMID 38331743, Free PMC Article
    5. Arabidopsis Flavonoid Mutants Are Hypersensitive to UV-B Irradiation. Li J, et al. Plant Cell, 1993 Feb. PMID 12271060, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
      Title: Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
    2. experiments indicate that the absence of F3H in these lines enables the synthesis of uncommon 3-deoxy flavonoids in the Arabidopsis seed coat
      Title: Biochemical and genetic characterization of Arabidopsis flavanone 3beta-hydroxylase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203121.1
    NM_114983.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavanone 3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavanone 3-dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flavonoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flavonoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flavonoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonoid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    flavanone 3-hydroxylase
    NP_001190050.1
    • flavanone 3-hydroxylase (F3H); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT4G10490.1).
    NP_190692.1
    • flavanone 3-hydroxylase (F3H); FUNCTIONS IN: naringenin 3-dioxygenase activity; INVOLVED IN: response to UV-B, response to sucrose stimulus, flavonoid biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT4G10500.1); Has 8311 Blast hits to 8276 proteins in 982 species: Archae - 0; Bacteria - 1082; Metazoa - 105; Fungi - 917; Plants - 4933; Viruses - 0; Other Eukaryotes - 1274 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19025192..19026872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114983.3 → NP_190692.1  flavanone 3-hydroxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38877, Q9C526, Q9C528, Q9C530, Q9C563, Q9C5V7, Q9S818
      UniProtKB/TrEMBL
      A0A5S9XJS4, Q5DWW0
      Conserved Domains (1) summary
      PLN02515
      Location:1 → 358
      PLN02515; naringenin,2-oxoglutarate 3-dioxygenase

    2. NM_001203121.1 → NP_001190050.1  flavanone 3-hydroxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J3A5
      Conserved Domains (3) summary
      PLN02515
      Location:1 → 274
      PLN02515; naringenin,2-oxoglutarate 3-dioxygenase
      pfam03171
      Location:110 → 210
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
      cl21672
      Location:1 → 36
      DIOX_N; non-haem dioxygenase in morphine synthesis N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S818.1

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