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    G6PD5 glucose-6-phosphate dehydrogenase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822349, updated on 18-Sep-2024

    Summary

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    Official Symbol
    G6PD5
    Official Full Name
    glucose-6-phosphate dehydrogenase 5
    Primary source
    TAIR:AT3G27300
    Locus tag
    AT3G27300
    See related
    Araport:AT3G27300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glucose-6-phosphate dehydrogenase 5
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    Genomic context

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    See G6PD5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (10083009..10086798, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene prohibitin 4 Neighboring gene miscRNA Neighboring gene RNI-like superfamily protein Neighboring gene plant UBX domain-containing protein 1 Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum. Linnenbrügger L, et al. Front Plant Sci, 2022. PMID 36119606, Free PMC Article
    2. Involvement of G6PD5 in ABA response during seed germination and root growth in Arabidopsis. Yang L, et al. BMC Plant Biol, 2019 Jan 30. PMID 30700259, Free PMC Article
    3. Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis. Wakao S, et al. Plant Physiol, 2008 Jan. PMID 17993547, Free PMC Article
    4. Genome-wide analysis of glucose-6-phosphate dehydrogenases in Arabidopsis. Wakao S, et al. Plant J, 2005 Jan. PMID 15634201
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. involvement in ABA response during seed germination and root growth
      Title: Involvement of G6PD5 in ABA response during seed germination and root growth in Arabidopsis.
    2. results suggest that loss of cytosolic G6PDH activity affects the metabolism of developing seeds by increasing carbon substrates for synthesis of storage compounds rather than by decreasing the NADPH supply specifically for fatty acid synthesis
      Title: Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001035703.3
    NM_001084745.1
    NM_001338866.1
    NM_001338867.1
    NM_113644.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pentose-phosphate shunt, oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate dehydrogenase 5
    NP_001030780.1
    • glucose-6-phosphate dehydrogenase 5 (G6PD5); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity; INVOLVED IN: response to cadmium ion, pentose-phosphate shunt, oxidative branch, glucose metabolic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, active site (InterPro:IPR019796), Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 6 (TAIR:AT5G40760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001078214.1
    • glucose-6-phosphate dehydrogenase 5 (G6PD5); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity; INVOLVED IN: pentose-phosphate shunt, oxidative branch, glucose metabolic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, active site (InterPro:IPR019796), Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 6 (TAIR:AT5G40760.1); Has 8384 Blast hits to 8367 proteins in 2341 species: Archae - 0; Bacteria - 5762; Metazoa - 904; Fungi - 180; Plants - 377; Viruses - 4; Other Eukaryotes - 1157 (source: NCBI BLink).
    NP_189366.1
    • glucose-6-phosphate dehydrogenase 5 (G6PD5); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity; INVOLVED IN: response to cadmium ion, pentose-phosphate shunt, oxidative branch, glucose metabolic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, active site (InterPro:IPR019796), Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 6 (TAIR:AT5G40760.1); Has 8384 Blast hits to 8367 proteins in 2341 species: Archae - 0; Bacteria - 5762; Metazoa - 904; Fungi - 180; Plants - 377; Viruses - 4; Other Eukaryotes - 1157 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10083009..10086798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113644.5 → NP_189366.1  glucose-6-phosphate dehydrogenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189366.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZD0, Q9LK23, Q9SUK0
      UniProtKB/TrEMBL
      A0A178VBL3, A0A5S9XG42, Q5E919
      Conserved Domains (3) summary
      PLN02539
      Location:15 → 509
      PLN02539; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35 → 221
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:224 → 511
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. NM_001035703.3 → NP_001030780.1  glucose-6-phosphate dehydrogenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZD0, Q9LK23, Q9SUK0
      UniProtKB/TrEMBL
      A0A178VBL3, A0A5S9XG42, Q5E919
      Conserved Domains (3) summary
      PLN02539
      Location:15 → 509
      PLN02539; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35 → 221
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:224 → 511
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. NM_001338866.1 → NP_001325679.1  glucose-6-phosphate dehydrogenase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VBL3, A0A1I9LLZ6, A0A5S9XG42

    4. NM_001084745.1 → NP_001078214.1  glucose-6-phosphate dehydrogenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZD0, Q9LK23, Q9SUK0
      UniProtKB/TrEMBL
      A0A178VBL3, A0A5S9XG42, Q5E919
      Conserved Domains (3) summary
      PLN02539
      Location:15 → 509
      PLN02539; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35 → 221
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:224 → 511
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    5. NM_001338867.1 → NP_001325680.1  glucose-6-phosphate dehydrogenase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VBL3, A0A1I9LLZ7, A0A5S9XG42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LK23.1

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