HXK1 hexokinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HXK1
Official Full Name: hexokinase 1
Primary source: TAIR:AT4G29130
Locus tag: AT4G29130
See related: Araport:AT4G29130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA HEXOKINASE 1; ATHXK1; F19B15.160; F19B15_160; GIN2; GLUCOSE INSENSITIVE 2; HEXOKINASE; hexokinase 1
Summary: Encodes a hexokinase (HXK1) in the plant glucose-signaling network. Functions as a glucose sensor to interrelate nutrient, light, and hormone signaling networks for controlling growth and development in response to the changing environment.
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Genomic context

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See HXK1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 7

Sequence:: Chromosome: 4; NC_003075.7 (14352037..14355201, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complex genetic interaction between glucose sensor HXK1 and E3 SUMO ligase SIZ1 in regulating plant morphogenesis.
Title: Complex genetic interaction between glucose sensor HXK1 and E3 SUMO ligase SIZ1 in regulating plant morphogenesis.
Combining proteome and metabolome analysis at subcellular resolution revealed that the hexokinase-1 mutant of Arabidopsis, gin2-1 , cannot respond adequately to sudden changes of light intensity, thus explaining its high light sensitivity.
Title: Subcellular dynamics of proteins and metabolites under abiotic stress reveal deferred response of the Arabidopsis thaliana hexokinase-1 mutant gin2-1 to high light.
Glucose-triggered stomatal closure may be dependent on basal signaling through PYR/RCAR receptors and hexokinase1 (HXK1).
Title: Glucose triggers stomatal closure mediated by basal signaling through HXK1 and PYR/RCAR receptors in Arabidopsis.
HXK1 regulates cell proliferation and expansion early during leaf development, and that HXK1 is involved in sucrose-induced leaf growth stimulation independent of GPT2.
Title: The role of HEXOKINASE1 in Arabidopsis leaf growth.
HXK1 affects the expression of PIPaquaporins genes and reduce leaf water conductance, to coordinate sugar levels with the loss of water through transpiration.
Title: Sugar and hexokinase suppress expression of PIP aquaporins and reduce leaf hydraulics that preserves leaf water potential.
role in cell death mediated by myo-inositol accumulation
Title: Involvement of Arabidopsis Hexokinase1 in Cell Death Mediated by Myo-Inositol Accumulation.
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
Title: Biochemical and structural study of Arabidopsis hexokinase 1.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
Title: Measuring whole plant CO2 exchange with the environment reveals opposing effects of the gin2-1 mutation in shoots and roots of Arabidopsis thaliana.
HXK1 mediated stimulation of NRT2.1 expression.
Title: Glucose elevates NITRATE TRANSPORTER2.1 protein levels and nitrate transport activity independently of its HEXOKINASE1-mediated stimulation of NITRATE TRANSPORTER2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Title: Regulation of nitrate reduction in Arabidopsis WT and hxk1 mutant under C and N metabolites.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119057.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hexose catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of secondary shoot formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of secondary shoot formation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in response to fructose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sugar mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within transpiration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: hexokinase 1

NP_194642.1

hexokinase 1 (HXK1); FUNCTIONS IN: fructokinase activity, hexokinase activity, glucokinase activity, zinc ion binding, ATP binding; INVOLVED IN: sugar mediated signaling pathway, hexose catabolic process, glucose mediated signaling pathway, programmed cell death; LOCATED IN: in 6 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, conserved site (InterPro:IPR019807), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: hexokinase 2 (TAIR:AT2G19860.1); Has 2426 Blast hits to 2148 proteins in 325 species: Archae - 0; Bacteria - 92; Metazoa - 1300; Fungi - 606; Plants - 290; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).