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    PAA2 20S proteasome subunit PAA2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAA2
    Official Full Name
    20S proteasome subunit PAA2
    Primary source
    TAIR:AT2G05840
    Locus tag
    AT2G05840
    See related
    Araport:AT2G05840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    20S proteasome subunit PAA2; T6P5.4; T6P5_4
    Summary
    Encodes 20S proteasome subunit PAA2 (PAA2).
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    Genomic context

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    See PAA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (2234019..2236470)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NagB/RpiA/CoA transferase-like superfamily protein Neighboring gene pseudo Neighboring gene serine carboxypeptidase-like 38

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Clp protease system is required for copper ion-dependent turnover of the PAA2/HMA8 copper transporter in chloroplasts. Tapken W, et al. New Phytol, 2015 Jan. PMID 25262970
    2. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
    3. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
    4. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
    5. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Copper excess in the stroma triggers selection of the thylakoid-localized PAA2 transporter for degradation by the Clp protease.
      Title: The Clp protease system is required for copper ion-dependent turnover of the PAA2/HMA8 copper transporter in chloroplasts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036263.1
    NM_001335288.1
    NM_126597.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in mitochondrion HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    20S proteasome subunit PAA2
    NP_001031340.1
    • 20S proteasome subunit PAA2 (PAA2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome; EXPRESSED IN: fruit, guard cell, cultured cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit A1 (TAIR:AT5G35590.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_178641.1
    • 20S proteasome subunit PAA2 (PAA2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome; EXPRESSED IN: fruit, guard cell, cultured cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit A1 (TAIR:AT5G35590.1); Has 5183 Blast hits to 5183 proteins in 442 species: Archae - 699; Bacteria - 0; Metazoa - 1674; Fungi - 1311; Plants - 685; Viruses - 0; Other Eukaryotes - 814 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2234019..2236470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126597.4 → NP_178641.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81147
      UniProtKB/TrEMBL
      A0A178VUX1, A0A5S9WXD7, A0A7G2FDQ8
      Conserved Domains (1) summary
      cd03754
      Location:8 → 220
      proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    2. NM_001335288.1 → NP_001324458.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B073

    3. NM_001036263.1 → NP_001031340.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FDQ8, F4IIA5
      Conserved Domains (2) summary
      TIGR03633
      Location:7 → 217
      arc_protsome_A; proteasome endopeptidase complex, archaeal, alpha subunit
      cd03754
      Location:8 → 217
      proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81147.1

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