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    PP2A-3 protein phosphatase 2A-3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818850, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PP2A-3
    Official Full Name
    protein phosphatase 2A-3
    Primary source
    TAIR:AT2G42500
    Locus tag
    AT2G42500
    See related
    Araport:AT2G42500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MHK10.22; PP2A-4; protein phosphatase 2A-3; protein phosphatase 2A-4
    Summary
    Encodes one of the isoforms of the catalytic subunit of protein phosphatase 2A: AT1G59830/PP2A-1, AT1G10430/PP2A-2, At2g42500/PP2A-3, At3g58500/PP2A-4 [Plant Molecular Biology (1993) 21:475-485 and (1994) 26:523-528; Note that in more recent publications, there is mixed use of gene names for PP2A-3 and PP2A-4 - some refer to At2g42500 as PP2A-3 and some as PP2A-4].
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    Genomic context

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    See PP2A-3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (17697626..17701417, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Copper amine oxidase family protein Neighboring gene survival motor neuron interacting protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene cold regulated 15b Neighboring gene cold-regulated 15a

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root. Yue K, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26792519, Free PMC Article
    2. Specialized functions of the PP2A subfamily II catalytic subunits PP2A-C3 and PP2A-C4 in the distribution of auxin fluxes and development in Arabidopsis. Ballesteros I, et al. Plant J, 2013 Mar. PMID 23167545
    3. The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Ahn CS, et al. Plant Cell, 2011 Jan. PMID 21216945, Free PMC Article
    4. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Tran HT, et al. Plant J, 2012 Jul. PMID 22404109
    5. TAP46 plays a positive role in the ABSCISIC ACID INSENSITIVE5-regulated gene expression in Arabidopsis. Hu R, et al. Plant Physiol, 2014 Feb. PMID 24357600, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PP2A-C3 and PP2A-C4, have redundant functions in controlling embryo patterning and root development, processes that depend on auxin fluxes.
      Title: Specialized functions of the PP2A subfamily II catalytic subunits PP2A-C3 and PP2A-C4 in the distribution of auxin fluxes and development in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202803.2
    NM_001336978.1
    NM_001336979.1
    NM_129811.4
    NM_201943.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 2A-3
    NP_001189732.1
    • protein phosphatase 2A-3 (PP2A-3); FUNCTIONS IN: hydrolase activity, protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-4 (TAIR:AT3G58500.1).
    NP_565974.1
    • protein phosphatase 2A-3 (PP2A-3); FUNCTIONS IN: hydrolase activity, protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-4 (TAIR:AT3G58500.1); Has 6823 Blast hits to 6634 proteins in 485 species: Archae - 80; Bacteria - 208; Metazoa - 2397; Fungi - 1409; Plants - 992; Viruses - 2; Other Eukaryotes - 1735 (source: NCBI BLink).
    NP_973672.1
    • protein phosphatase 2A-3 (PP2A-3); FUNCTIONS IN: hydrolase activity, protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-4 (TAIR:AT3G58500.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17697626..17701417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129811.4 → NP_565974.1  protein phosphatase 2A-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565974.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07100, Q7G9R3, Q9ZRF6
      UniProtKB/TrEMBL
      A0A178VSM5, A0A5S9X6D5, Q8LAT9
      Conserved Domains (1) summary
      cd07415
      Location:13 → 297
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_201943.2 → NP_973672.1  protein phosphatase 2A-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IN36
      Conserved Domains (2) summary
      smart00156
      Location:31 → 250
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07415
      Location:13 → 250
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    3. NM_001336978.1 → NP_001324021.1  protein phosphatase 2A-3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYS4

    4. NM_001336979.1 → NP_001324022.1  protein phosphatase 2A-3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYV1

    5. NM_001202803.2 → NP_001189732.1  protein phosphatase 2A-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IN38
      Conserved Domains (1) summary
      cl13995
      Location:13 → 165
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07100.2

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