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    UPL2 ubiquitin-protein ligase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843368, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPL2
    Official Full Name
    ubiquitin-protein ligase 2
    Primary source
    TAIR:AT1G70320
    Locus tag
    AT1G70320
    See related
    Araport:AT1G70320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17O7.15; F17O7_15; ubiquitin-protein ligase 2
    Summary
    encodes a ubiquitin-protein ligase-like protein containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.
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    Genomic context

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    See UPL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (26488454..26501652, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene spermidine synthase 2 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene dicer-like protein (DUF936) Neighboring gene equilibrative nucleotide transporter 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UPL1 and 2, two 405 kDa ubiquitin-protein ligases from Arabidopsis thaliana related to the HECT-domain protein family. Bates PW, et al. Plant J, 1999 Oct. PMID 10571878
    2. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
    3. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_105700.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-protein ligase 2
    NP_177189.1
    • ubiquitin-protein ligase 2 (UPL2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: cytosol, mitochondrion, ubiquitin ligase complex, nucleus; EXPRESSED IN: male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), E3 ubiquitin ligase, domain of unknown function DUF913 (InterPro:IPR010314), HECT (InterPro:IPR000569), Armadillo-type fold (InterPro:IPR016024), Ubiquitin interacting motif (InterPro:IPR003903), E3 ubiquitin ligase, domain of unknown function DUF908 (InterPro:IPR010309), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: ubiquitin-protein ligase 1 (TAIR:AT1G55860.2); Has 34660 Blast hits to 19733 proteins in 1213 species: Archae - 286; Bacteria - 8191; Metazoa - 9374; Fungi - 5439; Plants - 1788; Viruses - 520; Other Eukaryotes - 9062 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26488454..26501652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105700.3 → NP_177189.1  ubiquitin-protein ligase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64604, O64605, Q0WL35, Q8H0T4, Q9M7K6
      UniProtKB/TrEMBL
      A0A654EMQ3
      Conserved Domains (6) summary
      smart00119
      Location:3320 → 3655
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3296 → 3656
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14327
      Location:1275 → 1312
      UBA_atUPL1_2_like; UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins
      pfam06012
      Location:88 → 358
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:416 → 765
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2593 → 2688
      DUF4414; Domain of unknown function (DUF4414)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H0T4.3

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