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    KCR2 beta-ketoacyl reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839063, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCR2
    Official Full Name
    beta-ketoacyl reductase 2
    Primary source
    TAIR:AT1G24470
    Locus tag
    AT1G24470
    See related
    Araport:AT1G24470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKCR2; beta-ketoacyl reductase 2; F21J9.13
    Summary
    Encodes one of the two Arabidopsis homologues to YBR159w encoding a S. cerevisiae beta-ketoacyl reductase (KCR), which catalyzes the first reduction during VLCFA (very long chain fatty acids, >18 carbon) elongation: KCR1 (At1g67730), KCR2 (At1g24470). Complementation of the yeast ybr159Delta mutant demonstrated that the two KCR proteins are divergent and that only AtKCR1 can restore heterologous elongase activity similar to the native yeast KCR gene.
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    Genomic context

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    See KCR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (8673914..8676408)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ribonuclease III family protein Neighboring gene TGN-related, localized SYP41 interacting protein Neighboring gene uncharacterized protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ER protein carbohydrate-binding protein Neighboring gene OxaA/YidC-like membrane insertion protein Neighboring gene TCP-1/cpn60 chaperonin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Beaudoin F, et al. Plant Physiol, 2009 Jul. PMID 19439572, Free PMC Article
    2. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Beaudoin F, et al. J Biol Chem, 2002 Mar 29. PMID 11792704
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtKCR2 is not a functional beta-ketoacyl-coenzyme A reductase isoform.
      Title: Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_102292.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables acetoacetyl-CoA reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ketoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-ketoacyl reductase 2
    NP_173856.1
    • beta-ketoacyl reductase 2 (KCR2); FUNCTIONS IN: oxidoreductase activity, ketoreductase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: beta-ketoacyl reductase 1 (TAIR:AT1G67730.1); Has 80088 Blast hits to 80001 proteins in 3265 species: Archae - 726; Bacteria - 55481; Metazoa - 4714; Fungi - 3206; Plants - 2039; Viruses - 0; Other Eukaryotes - 13922 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8673914..8676408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102292.3 → NP_173856.1  beta-ketoacyl reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FYL6
      UniProtKB/TrEMBL
      A0A178WKN2
      Conserved Domains (2) summary
      PLN02780
      Location:8 → 309
      PLN02780; ketoreductase/ oxidoreductase
      cd05356
      Location:52 → 293
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FYL6.1

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