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    APX3 ascorbate peroxidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829652, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APX3
    Official Full Name
    ascorbate peroxidase 3
    Primary source
    TAIR:AT4G35000
    Locus tag
    AT4G35000
    See related
    Araport:AT4G35000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ascorbate peroxidase 3; ASCORBATE PEROXIDASE 3; M4E13.60; M4E13_60
    Summary
    Encodes a microsomal ascorbate peroxidase APX3. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms. The APX3 protein interacts with AKR2 (ankyrin-containing protein that interacts with AFT1) and AFT1, a 14-3-3 protein.
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    Genomic context

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    See APX3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (16664724..16667721, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene subtilisin-like serine protease 2 Neighboring gene myb domain protein 32 Neighboring gene beta-galactosidase 11 Neighboring gene RAC-like 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress. Wang J, et al. Plant Cell Physiol, 1999 Jul. PMID 10501032
    2. The Arabidopsis ascorbate peroxidase 3 is a peroxisomal membrane-bound antioxidant enzyme and is dispensable for Arabidopsis growth and development. Narendra S, et al. J Exp Bot, 2006. PMID 16873450
    3. Cloning and expression of an Arabidopsis gene encoding a putative peroxisomal ascorbate peroxidase. Zhang H, et al. Plant Mol Biol, 1997 Aug. PMID 9290648
    4. An ankyrin repeat-containing protein plays a role in both disease resistance and antioxidation metabolism. Yan J, et al. Plant J, 2002 Jan. PMID 11862948
    5. Is AKR2A an essential molecular chaperone for a class of membrane-bound proteins in plants? Zhang H, et al. Plant Signal Behav, 2010 Nov. PMID 21057222, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function in APX3 does not affect Arabidopsis growth and development.
      Title: The Arabidopsis ascorbate peroxidase 3 is a peroxisomal membrane-bound antioxidant enzyme and is dispensable for Arabidopsis growth and development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119666.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbate peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular oxidant detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    ascorbate peroxidase 3
    NP_195226.1
    • ascorbate peroxidase 3 (APX3); FUNCTIONS IN: L-ascorbate peroxidase activity; INVOLVED IN: response to oxidative stress; LOCATED IN: in 7 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 5 (TAIR:AT4G35970.1); Has 9863 Blast hits to 8656 proteins in 1251 species: Archae - 86; Bacteria - 3261; Metazoa - 20; Fungi - 794; Plants - 3685; Viruses - 0; Other Eukaryotes - 2017 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16664724..16667721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119666.4 → NP_195226.1  ascorbate peroxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195226.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81810, Q42564
      UniProtKB/TrEMBL
      A0A178UXW7, A0A5S9XYP8, A0A654FVY8
      Conserved Domains (1) summary
      PLN02608
      Location:1 → 287
      PLN02608; L-ascorbate peroxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42564.1

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