PUR2 Glycinamide ribonucleotide (GAR) synthetase [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: PUR2
Official Full Name: Glycinamide ribonucleotide (GAR) synthetase
Primary source: TAIR:AT1G09830
Locus tag: AT1G09830
See related: Araport:AT1G09830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F21M12.22; F21M12_22; purine biosynthesis 2
Summary: glycinamide ribonucleotide synthetase (GAR synthetase) that catalyzes the conversion of phosphoribosyl amine to phosphoribosyl glycineamide
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_100857.4

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed

NP_172454.1

Glycinamide ribonucleotide (GAR) synthetase; FUNCTIONS IN: phosphoribosylamine-glycine ligase activity; INVOLVED IN: purine base biosynthetic process, purine nucleotide biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribosylglycinamide synthetase, conserved site (InterPro:IPR020559), Phosphoribosylglycinamide synthetase, C-domain (InterPro:IPR020560), Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain (InterPro:IPR020561), ATP-grasp fold, subdomain 1 (InterPro:IPR013815), PreATP-grasp-like fold (InterPro:IPR016185), Phosphoribosylglycinamide synthetase, N-domain (InterPro:IPR020562), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054), Phosphoribosylglycinamide synthetase (InterPro:IPR000115); Has 12648 Blast hits to 12644 proteins in 2666 species: Archae - 340; Bacteria - 7373; Metazoa - 216; Fungi - 226; Plants - 88; Viruses - 0; Other Eukaryotes - 4405 (source: NCBI BLink).

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