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    Washc4 WASH complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314690, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Washc4provided by RGD
    Official Full Name
    WASH complex subunit 4provided by RGD
    Primary source
    RGD:1309995
    See related
    EnsemblRapid:ENSRNOG00000008331 AllianceGenome:RGD:1309995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309995
    Summary
    Predicted to be involved in endosomal transport and endosome organization. Predicted to act upstream of or within several processes, including endolysosomal toll-like receptor signaling pathway; neuromuscular process; and regulation of protein complex stability. Predicted to be located in nucleoplasm. Predicted to be part of BLOC-1 complex and WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 314.2), Spleen (RPKM 278.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Washc4 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22075546..22127847, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20187905..20240228, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26309279..26361221, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549680 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 Neighboring gene integral membrane protein 2A, pseudogene 1 Neighboring gene aldehyde dehydrogenase 1 family, member L2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα. Ryder PV, et al. Mol Biol Cell, 2013 Jul. PMID 23676666, Free PMC Article
    2. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
    3. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. Harbour ME, et al. J Cell Sci, 2010 Nov 1. PMID 20923837, Free PMC Article
    4. Retromer and sorting nexins in endosomal sorting. Gallon M, et al. Biochem Soc Trans, 2015 Feb. PMID 25619244
    5. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Derivery E, et al. Dev Cell, 2009 Nov. PMID 19922875

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endolysosomal toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WASH complex subunit 4
    Names
    WASH complex subunit 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399772.1 → NP_001386701.1  WASH complex subunit 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000011326.7, ENSRNOT00000011326.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22075546..22127847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241205.5 → XP_006241267.1  WASH complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006241267.1

      UniProtKB/TrEMBL
      A6IFG4, D4A7I6
      Conserved Domains (3) summary
      pfam14744
      Location:612 → 945
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:32 → 600
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:966 → 1135
      WASH-7_C; WASH complex subunit 7, C-terminal

    2. XM_008765293.3 → XP_008763515.1  WASH complex subunit 4 isoform X2

      See identical proteins and their annotated locations for XP_008763515.1

      UniProtKB/TrEMBL
      A6IFG5
      Conserved Domains (3) summary
      pfam14744
      Location:424 → 757
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1 → 412
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:778 → 947
      WASH-7_C; WASH complex subunit 7, C-terminal

    3. XM_039080078.2 → XP_038936006.1  WASH complex subunit 4 isoform X3

      Conserved Domains (3) summary
      pfam14744
      Location:117 → 461
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1 → 112
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:478 → 647
      WASH-7_C; WASH complex subunit 7, C-terminal

    RNA

    1. XR_005486803.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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