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    Syn3 synapsin III [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29130, updated on 27-Nov-2024

    Summary

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    Symbol
    Syn3provided by RGD
    Full Name
    synapsin IIIprovided by RGD
    Primary source
    RGD:3799
    See related
    EnsemblRapid:ENSRNOG00000026866 AllianceGenome:RGD:3799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ATP binding activity. Predicted to be involved in synapse organization and synaptic vesicle clustering. Located in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Orthologous to human SYN3 (synapsin III). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 40.9), Kidney (RPKM 19.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syn3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19244032..19701571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (16216055..17808790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (23403896..23808602)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479846 Neighboring gene sperm motility kinase W like 2 Neighboring gene TIMP metallopeptidase inhibitor 3 Neighboring gene uncharacterized LOC134479850 Neighboring gene uncharacterized LOC134479849 Neighboring gene U6 spliceosomal RNA Neighboring gene F-box protein 7 Neighboring gene BPI fold containing family C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of neurotransmitter release by synapsin III. Feng J, et al. J Neurosci, 2002 Jun 1. PMID 12040043, Free PMC Article
    2. Synapsin III, a novel synapsin with an unusual regulation by Ca2+. Hosaka M, et al. J Biol Chem, 1998 May 29. PMID 9593663
    3. A third member of the synapsin gene family. Kao HT, et al. Proc Natl Acad Sci U S A, 1998 Apr 14. PMID 9539796, Free PMC Article
    4. Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo. Perlini LE, et al. Cell Rep, 2015 Apr 14. PMID 25843720, Free PMC Article
    5. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, et al. Mol Biol Cell, 2007 Jul. PMID 17442889, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that SynIII phosphorylation at the CDK5 site is induced by activation of the semaphorin-3A (Sema3A) pathway, which is implicated in migration and orientation of cortical pyramidal neurons
      Title: Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synapsin-3
    Names
    synapsin-3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017109.2 → NP_058805.1  synapsin-3

      See identical proteins and their annotated locations for NP_058805.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O70441
      UniProtKB/TrEMBL
      A0A096MIT7, A6IFC2
      Related
      ENSRNOP00000036740.6, ENSRNOT00000037918.7
      Conserved Domains (4) summary
      PRK14971
      Location:380 → 530
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam02750
      Location:192 → 394
      Synapsin_C; Synapsin, ATP binding domain
      pfam02078
      Location:90 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      19244032..19701571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263103.1 → XP_063119173.1  synapsin-3 isoform X1

      UniProtKB/Swiss-Prot
      O70441
      UniProtKB/TrEMBL
      A6IFC2

    2. XM_063263102.1 → XP_063119172.1  synapsin-3 isoform X1

      UniProtKB/Swiss-Prot
      O70441
      UniProtKB/TrEMBL
      A6IFC2

    3. XM_063263105.1 → XP_063119175.1  synapsin-3 isoform X1

      UniProtKB/Swiss-Prot
      O70441
      UniProtKB/TrEMBL
      A6IFC2

    4. XM_063263104.1 → XP_063119174.1  synapsin-3 isoform X1

      UniProtKB/Swiss-Prot
      O70441
      UniProtKB/TrEMBL
      A6IFC2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70441.1 GenPept UniProtKB/Swiss-Prot:O70441

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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