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    ar androgen receptor [ Danio rerio (zebrafish) ]

    Gene ID: 100005148, updated on 9-Dec-2024

    Summary

    Official Symbol
    arprovided by ZNC
    Official Full Name
    androgen receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060131-1
    See related
    Ensembl:ENSDARG00000067976 AllianceGenome:ZFIN:ZDB-GENE-060131-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NR3C4
    Summary
    Enables androgen binding activity and nuclear steroid receptor activity. Acts upstream of or within several processes, including male courtship behavior; male gonad development; and oocyte maturation. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including Leydig cell; brain; digestive system; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (35561341..35680989)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (34961188..35080836)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-204l11.1 Neighboring gene cholesterol 25-hydroxylase like 3 Neighboring gene oligophrenin 1 Neighboring gene Yip1 domain family, member 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables androgen binding PubMed 
    enables estrogen response element binding  
    enables metal ion binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables nuclear steroid receptor activity PubMed 
    enables sequence-specific DNA binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    androgen receptor
    Names
    AR-A
    Ar beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083123.1 → NP_001076592.1  androgen receptor

      See identical proteins and their annotated locations for NP_001076592.1

      Status: PROVISIONAL

      Source sequence(s)
      EF427915
      UniProtKB/TrEMBL
      A0A8M1NDR7, A4GT83
      Related
      ENSDARP00000088795.3, ENSDART00000098022.4
      Conserved Domains (2) summary
      cd07173
      Location:507 → 588
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
      cl11397
      Location:622 → 867
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      35561341..35680989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171775.3 → XP_005171832.1  androgen receptor isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJ05
      Conserved Domains (2) summary
      cd07173
      Location:24 → 105
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
      cl11397
      Location:139 → 384
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394592.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      28273..149588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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