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    adra2b adrenoceptor alpha 2B [ Danio rerio (zebrafish) ]

    Gene ID: 266751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adra2bprovided by ZNC
    Official Full Name
    adrenoceptor alpha 2Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021010-2
    See related
    Ensembl:ENSDARG00000102096 AllianceGenome:ZFIN:ZDB-GENE-021010-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb43d01; wu:fb43d01; zgc:194747
    Summary
    Enables alpha2-adrenergic receptor activity. Involved in adenylate cyclase-inhibiting adrenergic receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; eye; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See adra2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40644871..40646400)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40605306..40606835)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene izumo sperm-oocyte fusion 1 Neighboring gene dual specificity phosphatase 2 Neighboring gene uncharacterized LOC137496303 Neighboring gene uncharacterized LOC110440018

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of alpha-adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions. Ruuskanen JO, et al. J Neurochem, 2005 Sep. PMID 16000146
    2. Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors. Ruuskanen JO, et al. Br J Pharmacol, 2005 Jan. PMID 15655522, Free PMC Article
    3. Alpha-2 adrenoceptor subtypes: are more better? Bylund DB. Br J Pharmacol, 2005 Jan. PMID 15655520, Free PMC Article
    4. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Mei Y, et al. Endocrinology, 2013 Dec. PMID 24080366
    5. Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Cunha V, et al. Chemosphere, 2018 Jan. PMID 29145140

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-adrenergic receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables alpha2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-2B adrenergic receptor
    Names
    adrenergic, alpha-2B-, receptor
    alpha(2B)AR
    alpha-2B adrenoceptor
    alpha-2B adrenoreceptor
    alpha-2BAR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207638.1 → NP_997521.1  alpha-2B adrenergic receptor

      See identical proteins and their annotated locations for NP_997521.1

      Status: PROVISIONAL

      Source sequence(s)
      AY048970
      UniProtKB/Swiss-Prot
      Q90WY5
      Related
      ENSDARP00000130082.1, ENSDART00000169311.2
      Conserved Domains (2) summary
      pfam00001
      Location:58 → 244
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:50 → 178
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      40644871..40646400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90WY5.1 GenPept UniProtKB/Swiss-Prot:Q90WY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.