ifnphi1 interferon phi 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ifnphi1provided by ZNC
Official Full Name: interferon phi 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030721-3
See related: Ensembl:ENSDARG00000025607 AllianceGenome:ZFIN:ZDB-GENE-030721-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ifn; ifn1; ifnab
Summary: Predicted to enable cytokine receptor binding activity. Acts upstream of or within several processes, including defense response to other organism; regulation of defense response to virus by host; and response to exogenous dsRNA. Predicted to be located in extracellular region. Is expressed in brain; gill; immune system; integument; and liver. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (22362358..22366045, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (22232222..22235514, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Broad-Spectrum Robust Direct Bactericidal Activity of Fish IFNphi1 Reveals an Antimicrobial Peptide-like Function for Type I IFNs in Vertebrates.
Title: Broad-Spectrum Robust Direct Bactericidal Activity of Fish IFNφ1 Reveals an Antimicrobial Peptide-like Function for Type I IFNs in Vertebrates.
Following spring viremia of carp virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
Title: Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes.
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
Title: Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7.
Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.
Title: Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome.
Interferon regulatory factor (IRF)10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Title: IFN regulatory factor 10 is a negative regulator of the IFN responses in fish.
We conducted a microarray analysis of the larval zebrafish IFN response to two models of RNA virus infections
Title: Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.
IFN phi 1 and IFN phi 2 structures reported here reveal a characteristic type I IFN architecture with a straight F helix, as opposed to the remaining class II cytokines, including IFN-lambda, where helix F contains a characteristic bend.
Title: Crystal structure of Zebrafish interferons I and II reveals conservation of type I interferon structure in vertebrates.
IFNphi1 and IFNphi2 bind different receptors
Title: The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon phi 1

Names: interferon 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.