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    prickle2b prickle homolog 2b [ Danio rerio (zebrafish) ]

    Gene ID: 368250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prickle2bprovided by ZNC
    Official Full Name
    prickle homolog 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030724-6
    See related
    Ensembl:ENSDARG00000037593 AllianceGenome:ZFIN:ZDB-GENE-030724-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pk2; cb886; prickle2; im:7138215
    Summary
    Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; melanosome transport; and neural retina development. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neural tube. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prickle2b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (19273979..19469072)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (19109037..19306737)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496751 Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene transfer RNA valine (anticodon CAC) Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene uncharacterized LOC137496690 Neighboring gene uncharacterized LOC137496745 Neighboring gene solute carrier family 2 member 9, like 1 Neighboring gene proteasome 26S subunit, non-ATPase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman MT, et al. Curr Biol, 2003 Apr 15. PMID 12699626
    2. Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Mei X, et al. Dev Biol, 2014 Aug 15. PMID 24938409, Free PMC Article
    3. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Tao H, et al. Am J Hum Genet, 2011 Feb 11. PMID 21276947, Free PMC Article
    4. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Bassuk AG, et al. Am J Hum Genet, 2008 Nov. PMID 18976727, Free PMC Article
    5. Functional and evolutionary insights from the Ciona notochord transcriptome. Reeves WM, et al. Development, 2017 Sep 15. PMID 28928284, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish pk2 modulates convergence and extension movements in gastrulation, and retinal neurogenesis.
      Title: Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within melanosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neural retina development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prickle-like protein 2b
    Names
    prickle homolog 2
    prickle-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183343.1 → NP_899186.1  prickle-like protein 2b

      See identical proteins and their annotated locations for NP_899186.1

      Status: PROVISIONAL

      Source sequence(s)
      AY278987
      UniProtKB/TrEMBL
      Q7ZZC4
      Related
      ENSDARP00000135945.1, ENSDART00000162081.2
      Conserved Domains (4) summary
      cd09415
      Location:126 → 184
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:189 → 244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249 → 307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:22 → 118
      PET_Prickle; The PET domain of Prickle

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      19273979..19469072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224119.1 → XP_068080220.1  prickle-like protein 2b isoform X1

      Related
      ENSDARP00000145076.1, ENSDART00000181679.1

    2. XM_005155827.4 → XP_005155884.1  prickle-like protein 2b isoform X2

      See identical proteins and their annotated locations for XP_005155884.1

      UniProtKB/TrEMBL
      A0A8M2B1U8, F1REQ6
      Related
      ENSDARP00000146432.1, ENSDART00000186154.1
      Conserved Domains (4) summary
      cd09415
      Location:126 → 184
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:189 → 244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249 → 307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:22 → 118
      PET_Prickle; The PET domain of Prickle
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.