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    syk spleen tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 405769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sykprovided by ZNC
    Official Full Name
    spleen tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040702-3
    See related
    Ensembl:ENSDARG00000008186 AllianceGenome:ZFIN:ZDB-GENE-040702-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See syk in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5533840..5591951, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5533536..5591675, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene nuclear factor, interleukin 3 regulated Neighboring gene AU RNA binding protein/enoyl-CoA hydratase Neighboring gene DIRAS family GTPase 2 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Neighboring gene peptidylglycine alpha-amidating monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syk and Zap-70 function redundantly to promote angioblast migration. Christie TL, et al. Dev Biol, 2010 Apr 1. PMID 20096681
    2. Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Park G, et al. Oncotarget, 2020 Apr 14. PMID 32341750, Free PMC Article
    3. Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). Chen X, et al. Sci Total Environ, 2021 Sep 15. PMID 33991914
    4. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. Maugars G, et al. PLoS One, 2014. PMID 25386660, Free PMC Article
    5. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lymphangiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutrophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell migration involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen protein tyrosine kinase
    NP_998008.2
    XP_005155595.1
    XP_005155596.1
    XP_021334822.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212843.2 → NP_998008.2  tyrosine-protein kinase SYK

      Status: VALIDATED

      Source sequence(s)
      CD284981, CU466285, FP102769
      UniProtKB/TrEMBL
      A0A0R4IBB3, A0A8M1PIE3, E9QFU7
      Related
      ENSDARP00000122788.4, ENSDART00000141943.4
      Conserved Domains (3) summary
      cd05116
      Location:325 → 581
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159 → 260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      5533840..5591951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155539.5 → XP_005155596.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005155596.1

      UniProtKB/TrEMBL
      A0A8M2B201, F1QFN4
      Conserved Domains (4) summary
      cd05116
      Location:348 → 604
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159 → 260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:349 → 599
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_021479147.2 → XP_021334822.1  tyrosine-protein kinase SYK isoform X2

      UniProtKB/TrEMBL
      A0A0R4IBB3, A0A8M1PIE3, E9QFU7
      Related
      ENSDARP00000132135.1, ENSDART00000164558.2
      Conserved Domains (3) summary
      cd05116
      Location:325 → 581
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159 → 260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_005155538.5 → XP_005155595.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005155595.1

      UniProtKB/TrEMBL
      A0A8M2B201, F1QFN4
      Related
      ENSDARP00000003321.7, ENSDART00000005292.8
      Conserved Domains (4) summary
      cd05116
      Location:348 → 604
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159 → 260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:349 → 599
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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