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    gale UDP-galactose-4-epimerase [ Danio rerio (zebrafish) ]

    Gene ID: 678540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    galeprovided by ZNC
    Official Full Name
    UDP-galactose-4-epimeraseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-6479
    See related
    Ensembl:ENSDARG00000002401 AllianceGenome:ZFIN:ZDB-GENE-060421-6479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb05f01; im:7147391; wu:fb05f01; zgc:136578
    Summary
    Predicted to enable UDP-glucose 4-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to act upstream of or within galactose metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gale in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (24880322..24890859, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (24861921..24872527, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase Neighboring gene zinc finger and BTB domain containing 8A Neighboring gene si:ch211-195o20.7 Neighboring gene zgc:193593

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fatty liver disease induced by perfluorooctane sulfonate: Novel insight from transcriptome analysis. Fai Tse WK, et al. Chemosphere, 2016 Sep. PMID 27289203
    2. Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network. Kang Q, et al. Int J Mol Sci, 2020 Jan 22. PMID 31979106, Free PMC Article
    3. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
    4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136578

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables UDP-glucose 4-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose 4-epimerase
    NP_001035389.1
    XP_005158580.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040299.1 → NP_001035389.1  UDP-glucose 4-epimerase

      See identical proteins and their annotated locations for NP_001035389.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115183
      UniProtKB/TrEMBL
      Q1RM15
      Related
      ENSDARP00000154239.1, ENSDART00000184984.1
      Conserved Domains (2) summary
      cd05247
      Location:4 → 337
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
      TIGR01179
      Location:4 → 339
      galE; UDP-glucose-4-epimerase GalE

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      24880322..24890859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158523.4 → XP_005158580.1  UDP-glucose 4-epimerase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5E6, F1Q5H4
      Related
      ENSDARP00000117350.1, ENSDART00000135569.3
      Conserved Domains (2) summary
      cd05247
      Location:4 → 338
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
      TIGR01179
      Location:4 → 340
      galE; UDP-glucose-4-epimerase GalE
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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