suclg1 succinate-CoA ligase GDP/ADP-forming subunit alph [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: suclg1provided by ZNC
Official Full Name: succinate-CoA ligase GDP/ADP-forming subunit alphprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-101
See related: Ensembl:ENSDARG00000052712 AllianceGenome:ZFIN:ZDB-GENE-040912-101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92738; zgc:103729
Summary: Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (43652480..43684552, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (42951316..42983388, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (ADP-forming) activity	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (GDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of succinate-CoA ligase complex (ADP-forming)	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Names: SUCLGa; succinate-CoA ligase, GDP-forming, alpha subunit; succinate-CoA ligase, alpha subunit

NP_001002577.2

EC 6.2.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002577.2 → NP_001002577.2 succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

See identical proteins and their annotated locations for NP_001002577.2

Status: PROVISIONAL

Source sequence(s)

BC081520

UniProtKB/TrEMBL

Q66I58

Related

ENSDARP00000069096.4, ENSDART00000074609.5

Conserved Domains (3) summary

PTZ00187
Location:8 → 322

PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional

pfam00549
Location:177 → 302

Ligase_CoA; CoA-ligase

pfam02629
Location:31 → 124

CoA_binding; CoA binding domain