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    eef1a1a eukaryotic translation elongation factor 1 alpha 1a [ Danio rerio (zebrafish) ]

    Gene ID: 336334, updated on 15-Dec-2024

    Summary

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    Official Symbol
    eef1a1aprovided by ZNC
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8278
    See related
    Ensembl:ENSDARG00000039502 AllianceGenome:ZFIN:ZDB-GENE-030131-8278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj64c02; zgc:73138; wu:fj64c02
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm. Is expressed in asteriscus; brain; liver; muscle; and pleuroperitoneal region. Orthologous to several human genes including EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eef1a1a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (27314798..27324747)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (27184348..27194297)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2a Neighboring gene uncharacterized LOC137487403 Neighboring gene solute carrier family 17 member 5 Neighboring gene cyclic GMP-AMP synthase a Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish. Idigo NJ, et al. Biosci Rep, 2020 Jan 31. PMID 31950975, Free PMC Article
    2. Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment. Brañas Casas R, et al. Cell Death Dis, 2024 Apr 20. PMID 38643274, Free PMC Article
    3. Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio). van der Ven K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Aug. PMID 15979371
    4. Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death. Cao S, et al. Hum Mol Genet, 2017 Sep 15. PMID 28911200, Free PMC Article
    5. Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Antón-Galindo E, et al. Transl Psychiatry, 2024 Feb 19. PMID 38374212, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-alpha 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200009.2 → NP_956303.1  elongation factor 1-alpha 1a

      See identical proteins and their annotated locations for NP_956303.1

      Status: VALIDATED

      Source sequence(s)
      BX323884, EB940931, EB942310, EB968777, EH475805
      UniProtKB/TrEMBL
      A0A0R4IJ37, A0A8M1PAN1, Q6P969
      Related
      ENSDARP00000104468.2, ENSDART00000128726.4
      Conserved Domains (4) summary
      PTZ00141
      Location:1 → 460
      PTZ00141; elongation factor 1- alpha; Provisional
      cd01883
      Location:9 → 238
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      cd03693
      Location:242 → 332
      EF1_alpha_II; Domain II of elongation factor 1-alpha
      cd03705
      Location:336 → 438
      EF1_alpha_III; Domain III of Elongation Factor 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      27314798..27324747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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