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    tmem237b transmembrane protein 237b [ Danio rerio (zebrafish) ]

    Gene ID: 447898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem237bprovided by ZNC
    Official Full Name
    transmembrane protein 237bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-63
    See related
    Ensembl:ENSDARG00000074248 AllianceGenome:ZFIN:ZDB-GENE-040912-63
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    als2cr4b; sb:cb992; zgc:101660
    Summary
    Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in cilium and membrane. Predicted to be active in ciliary transition zone. Is expressed in central nervous system; pectoral fin bud; pharyngeal arch 3-7; and visual system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tmem237b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9898683..9916534)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9663144..9681003)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495837 Neighboring gene MAGUK p55 scaffold protein 4b Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene zona pellucida glycoprotein 2, like 2 Neighboring gene cytochrome P450, family 20, subfamily A, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish. Nadolski NJ, et al. Invest Ophthalmol Vis Sci, 2020 Apr 9. PMID 32293666, Free PMC Article
    2. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Huang L, et al. Am J Hum Genet, 2011 Dec 9. PMID 22152675, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 237B
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4b
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004636.1 → NP_001004636.1  transmembrane protein 237B

      See identical proteins and their annotated locations for NP_001004636.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081384
      UniProtKB/Swiss-Prot
      Q66IE4
      Related
      ENSDARP00000010454.5, ENSDART00000005573.7
      Conserved Domains (1) summary
      pfam15383
      Location:145 → 389
      TMEM237; Transmembrane protein 237

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9898683..9916534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302154.4 → XP_009300429.1  transmembrane protein 237B isoform X1

      UniProtKB/TrEMBL
      A0A8M3AT44
      Related
      ENSDART00000151743.3
      Conserved Domains (1) summary
      pfam15383
      Location:146 → 390
      TMEM237; Transmembrane protein 237

    2. XM_068221705.1 → XP_068077806.1  transmembrane protein 237B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66IE4.1 GenPept UniProtKB/Swiss-Prot:Q66IE4

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