igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf2bp3provided by ZNC
Official Full Name: insulin-like growth factor 2 mRNA binding protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-000308-1
See related: Ensembl:ENSDARG00000010266 AllianceGenome:ZFIN:ZDB-GENE-000308-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dvr1rbp; zVg1RBP; wu:fb79c12; wu:fe06h09
Summary: Enables mRNA 3'-UTR binding activity. Acts upstream of or within several processes, including germ cell migration; regulation of embryonic development; and sex determination. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Is expressed in female organism; male organism; oocyte stage I; oocyte stage IV; and oocyte stage V. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (20201289..20245494)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (20616654..20661378)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.
Title: The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.
Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.
Title: Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi73h09.y1 (e-PCR)
- UniSTS:197950

fe06h09.x1 (e-PCR)
- UniSTS:196040

fb79c12.x1 (e-PCR)
- UniSTS:191478

fb79c12.x1 (e-PCR)
- UniSTS:191479

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sex determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 3

Names: IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IMP3; VICKZ family member 3; Vg1 RBP; decapentaplegic and Vg-related 1 RNA-binding protein; vg1 RNA-binding protein; vg1-RBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131491.2 → NP_571566.1 insulin-like growth factor 2 mRNA-binding protein 3

See identical proteins and their annotated locations for NP_571566.1

Status: PROVISIONAL

Source sequence(s)

BC045873

UniProtKB/Swiss-Prot

Q9PW80

UniProtKB/TrEMBL

B2GT58

Related

ENSDARP00000010878.6, ENSDART00000010140.7

Conserved Domains (3) summary

cd00105
Location:278 → 343

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

20201289..20245494

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009294198.4 → XP_009292473.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

UniProtKB/TrEMBL

A0A0R4IYT0, A0A8M3AKY0

Related

ENSDARP00000140941.1, ENSDART00000163026.2

Conserved Domains (3) summary

cd00105
Location:278 → 343

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)