fbxw4 F-box and WD repeat domain containing 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxw4provided by ZNC
Official Full Name: F-box and WD repeat domain containing 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-000516-1
See related: Ensembl:ENSDARG00000033551 AllianceGenome:ZFIN:ZDB-GENE-000516-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dac; hag; fk63g06; hagoromo; wu:fk63g06
Summary: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28512877..28561512)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28382224..28431062)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 4

Names: F-box and WD-40 domain protein 4; dactylaplasia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131521.2 → NP_571596.1 F-box/WD repeat-containing protein 4

See identical proteins and their annotated locations for NP_571596.1

Status: PROVISIONAL

Source sequence(s)

AB022162

UniProtKB/TrEMBL

A0A2R8Q510, F6P8X0, Q9IBH3

Related

ENSDARP00000043116.5, ENSDART00000043117.6

Conserved Domains (4) summary

COG2319
Location:125 → 376

WD40; WD40 repeat [General function prediction only]

pfam12937
Location:5 → 46

F-box-like; F-box-like

sd00039
Location:181 → 217

7WD40; WD40 repeat [structural motif]

cl02567
Location:134 → 368

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...