U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fzd5 frizzled class receptor 5 [ Danio rerio (zebrafish) ]

    Gene ID: 30364, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fzd5provided by ZNC
    Official Full Name
    frizzled class receptor 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-218
    See related
    Ensembl:ENSDARG00000025420 AllianceGenome:ZFIN:ZDB-GENE-990415-218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fz2; Fz-5; fz8c; zg02; fzd8c
    Summary
    Enables Wnt receptor activity. Involved in eye development and non-canonical Wnt signaling pathway. Acts upstream of or within several processes, including liver development; negative regulation of canonical Wnt signaling pathway; and swim bladder development. Predicted to be located in several cellular components, including Golgi membrane; dendrite; and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Used to study coloboma. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fzd5 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28232522..28234444)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (28421776..28423698)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene pleckstrin homology domain containing, family M, member 3 Neighboring gene cyclin Y-like 1 Neighboring gene cAMP responsive element binding protein 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Liu C, et al. Hum Mol Genet, 2016 Apr 1. PMID 26908622, Free PMC Article
    2. Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm. Ungar AR, et al. Mech Dev, 2002 Oct. PMID 12351181
    3. Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Poulain M, et al. Development, 2011 Aug. PMID 21771809, Free PMC Article
    4. The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. Greenfeld H, et al. PLoS Biol, 2021 Jan. PMID 33481775, Free PMC Article
    5. A systematic survey of expression and function of zebrafish frizzled genes. Nikaido M, et al. PLoS One, 2013. PMID 23349976, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within swim bladder development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    frizzled-5
    Names
    Fz5
    frizzled homolog 2
    frizzled homolog 5
    frizzled homolog 8c

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131134.2 → NP_571209.2  frizzled-5 precursor

      See identical proteins and their annotated locations for NP_571209.2

      Status: PROVISIONAL

      Source sequence(s)
      BC163118
      UniProtKB/Swiss-Prot
      B3DIG4, B3DIG6, F6NK29
      Related
      ENSDARP00000036600.4, ENSDART00000031761.5
      Conserved Domains (2) summary
      cd07456
      Location:44 → 163
      CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
      cd15249
      Location:235 → 546
      7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      28232522..28234444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DIG4.1 GenPept UniProtKB/Swiss-Prot:B3DIG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.