mhc2dab major histocompatibility complex class II DAB gene [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc2dabprovided by ZNC
Official Full Name: major histocompatibility complex class II DAB geneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-200
See related: Ensembl:ENSDARG00000079105 AllianceGenome:ZFIN:ZDB-GENE-980526-200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DAB; DAB1; dab101; dab201; dab301; dab401; dab402; dab1*01; dab2*01; dab3*01; dab4*01; dab4*02; mhc2deb; mhciidab; zgc:110349; zgc:123077; zgc:152682; zgc:158870; mhc2d8.37b3; si:dkeyp-2h4.1
Summary: Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (36466771..36469124, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (36434989..36436660, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental gene expression pattern of reelin, dab1, vldlr, and apoer2 in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.
Title: Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period.

Submit: New GeneRIF Correction

General gene information

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Markers

fb33e09 (e-PCR)
- UniSTS:204670

fl03d03.x1 (e-PCR)
- UniSTS:201868

fj14b09.x1 (e-PCR)
- UniSTS:198591

Clone Names

MGC110349, MGC123077, MGC152682, MGC158870, MGC191506

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: major histocompatibility complex class II DAB

Names: Brre-DAB1*04; MHC Brre-DAB4; MHC Brre-DEB; MHC class II antigen; major histocompatibility complex class II DA-beta-101; major histocompatibility complex class II DA-beta-201; major histocompatibility complex class II DA-beta-301; major histocompatibility complex class II DA-beta-401; major histocompatibility complex class II DA-beta-402; major histocompatibility complex class II DEB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131476.3 → NP_571551.3 major histocompatibility complex class II DAB precursor

Status: VALIDATED

Source sequence(s)

CU694380

UniProtKB/TrEMBL

Q1MTC8, Q8MGW8

Related

ENSDARP00000100252.3, ENSDART00000111240.5

Conserved Domains (2) summary

pfam00969
Location:29 → 104

MHC_II_beta; Class II histocompatibility antigen, beta domain

pfam07654
Location:114 → 197

C1-set; Immunoglobulin C1-set domain