psma2a proteasome 20S subunit alpha 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psma2aprovided by ZNC
Official Full Name: proteasome 20S subunit alpha 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-479
See related: Ensembl:ENSDARG00000040121 AllianceGenome:ZFIN:ZDB-GENE-050522-479
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: psma2; wu:fb98h03; zgc:110710; wu:faa49c06
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (43336570..43344870, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (43432812..43441112, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome subunit alpha type-2

Names: proteasome (prosome, macropain) subunit, alpha type, 2; proteasome 20S subunit alpha 2; proteasome subunit alpha 2

NP_001019612.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024441.1 → NP_001019612.1 proteasome subunit alpha type-2

See identical proteins and their annotated locations for NP_001019612.1

Status: PROVISIONAL

Source sequence(s)

BC095382

UniProtKB/TrEMBL

A0A8M1N6V3, Q4VBR8

Related

ENSDARP00000058679.2, ENSDART00000058680.3

Conserved Domains (1) summary

cd03750
Location:6 → 231

proteasome_alpha_type_2; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...