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    ppp1cbl protein phosphatase 1, catalytic subunit, beta isoform, like [ Danio rerio (zebrafish) ]

    Gene ID: 334597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp1cblprovided by ZNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, beta isoform, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6529
    See related
    Ensembl:ENSDARG00000102012 AllianceGenome:ZFIN:ZDB-GENE-030131-6529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64169; wu:fa14b10; Pp1alpha-96A
    Summary
    Enables protein heterodimerization activity. Acts upstream of or within convergent extension involved in axis elongation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See ppp1cbl in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (74150840..74154873)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (74070006..74074040)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene receptor-type tyrosine-protein phosphatase delta-like Neighboring gene zgc:112102 Neighboring gene RNA binding protein, mRNA processing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A bioinformatic and computational study of myosin phosphatase subunit diversity. Dippold RP, et al. Am J Physiol Regul Integr Comp Physiol, 2014 Aug 1. PMID 24898838, Free PMC Article
    2. Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit. Jayashankar V, et al. PLoS One, 2013. PMID 24040418, Free PMC Article
    3. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1, catalytic subunit, beta isoform, like
    Names
    PPP1CBb
    Protein phosphatase 1alpha at 96A
    NP_956210.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199916.1 → NP_956210.1  protein phosphatase 1, catalytic subunit, beta isoform, like

      See identical proteins and their annotated locations for NP_956210.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053296
      UniProtKB/TrEMBL
      Q1JPZ8, Q7T313
      Related
      ENSDARP00000131101.2, ENSDART00000160195.2
      Conserved Domains (2) summary
      PTZ00480
      Location:3 → 254
      PTZ00480; serine/threonine-protein phosphatase; Provisional
      cl13995
      Location:7 → 251
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      74150840..74154873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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