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    cyp2aa6 cytochrome P450, family 2, subfamily AA, polypeptide 6 [ Danio rerio (zebrafish) ]

    Gene ID: 324212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp2aa6provided by ZNC
    Official Full Name
    cytochrome P450, family 2, subfamily AA, polypeptide 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2932
    See related
    Ensembl:ENSDARG00000103590 AllianceGenome:ZFIN:ZDB-GENE-030131-2932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc21h01; wu:fc21h01; si:ch73-73d17.3
    Summary
    Predicted to enable aromatase activity; heme binding activity; and iron ion binding activity. Predicted to be located in membrane. Is expressed in liver. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
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    Genomic context

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    See cyp2aa6 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (42316051..42330488)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (42350557..42364992)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene cytochrome P450, family 2, subfamily AA, polypeptide 12 Neighboring gene cytochrome P450, family 2, subfamily AA, polypeptide 11 Neighboring gene cytochrome P450, family 2, subfamily AA, polypeptide 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella). Shi XC, et al. Fish Physiol Biochem, 2018 Aug. PMID 29725939
    2. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Kubota A, et al. Toxicol Appl Pharmacol, 2013 Oct 1. PMID 23726801, Free PMC Article
    3. Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Puthumana J, et al. Aquat Toxicol, 2017 Jun. PMID 28411468
    4. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. Goldstone JV, et al. BMC Genomics, 2010 Nov 18. PMID 21087487, Free PMC Article
    5. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2AA6
    NP_001186898.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199969.3 → NP_001186898.2  cytochrome P450 2AA6

      Status: VALIDATED

      Source sequence(s)
      EH608876, FP015919
      UniProtKB/TrEMBL
      A0A8M1NWJ8
      Related
      ENSDART00000163730.2
      Conserved Domains (1) summary
      pfam00067
      Location:40 → 490
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      42316051..42330488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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