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    pknox1.1 pbx/knotted 1 homeobox 1.1 [ Danio rerio (zebrafish) ]

    Gene ID: 798151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pknox1.1provided by ZNC
    Official Full Name
    pbx/knotted 1 homeobox 1.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020122-5
    See related
    Ensembl:ENSDARG00000018765 AllianceGenome:ZFIN:ZDB-GENE-020122-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prep1; fc13f10; prep1.1; wu:fc13f10
    Summary
    Enables sequence-specific DNA binding activity. Acts upstream of or within hindbrain development and neural crest cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; germ ring; otic vesicle; ovary; and post-vent region. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pknox1.1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (19529883..19550398)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (19719014..19739529)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-140m22.7 Neighboring gene NADH:ubiquinone oxidoreductase subunit V3 Neighboring gene transmembrane serine protease 3a Neighboring gene fibroblast growth factor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Deflorian G, et al. Development, 2004 Feb. PMID 14711874
    2. Meis family proteins are required for hindbrain development in the zebrafish. Choe SK, et al. Development, 2002 Feb. PMID 11830560
    3. Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1. Bernardi E, et al. PLoS One, 2010 Dec 22. PMID 21203543, Free PMC Article
    4. Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Waskiewicz AJ, et al. Development, 2001 Nov. PMID 11684652
    5. TALE factors poise promoters for activation by Hox proteins. Choe SK, et al. Dev Cell, 2014 Jan 27. PMID 24480644, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the regulatory region of the zebrafish Prep1.1 gene and the promoter of human PREP1
      Title: Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
    2. Has a unique genetic function in craniofacial chondrogenesis and it plays an essential role in hindbrain development.
      Title: Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66244

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein PKNOX1.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131891.3 → NP_571966.3  homeobox protein PKNOX1.1

      See identical proteins and their annotated locations for NP_571966.3

      Status: VALIDATED

      Source sequence(s)
      BX294175
      UniProtKB/TrEMBL
      Q78BL1, Q90VY7
      Related
      ENSDARP00000111569.4, ENSDART00000125416.7
      Conserved Domains (2) summary
      pfam05920
      Location:284 → 323
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:82 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      19529883..19550398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304649.4 → XP_009302924.1  homeobox protein PKNOX1.1 isoform X1

      See identical proteins and their annotated locations for XP_009302924.1

      UniProtKB/TrEMBL
      Q78BL1, Q90VY7
      Conserved Domains (2) summary
      pfam05920
      Location:284 → 323
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:82 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein Strain
    Heading Accession and Version

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