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    pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 327453, updated on 4-Jan-2025

    Summary

    Official Symbol
    pfkfb1provided by ZNC
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5664
    See related
    Ensembl:ENSDARG00000037140 AllianceGenome:ZFIN:ZDB-GENE-030131-5664
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55328; wu:fi11h10
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Predicted to be active in cytosol. Is expressed in neural plate; neural tube; and somite. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See pfkfb1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (26017227..26037974)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (26090686..26111433)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-78k11.9 Neighboring gene cellular communication network factor 5 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene GDP dissociation inhibitor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
    Names
    6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
    NP_956102.1
    XP_005162206.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199808.1NP_956102.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

      See identical proteins and their annotated locations for NP_956102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044142
      UniProtKB/TrEMBL
      A8E5M1, Q803Y6
      Related
      ENSDARP00000028010.8, ENSDART00000002939.10
      Conserved Domains (3) summary
      pfam00300
      Location:240423
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:21237
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:29184
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      26017227..26037974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162149.5XP_005162206.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9A7, A2AR70
      Related
      ENSDARP00000113716.1, ENSDART00000141553.2
      Conserved Domains (3) summary
      pfam00300
      Location:253436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:28250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:42197
      AAA_33; AAA domain