dhrs12la dehydrogenase/reductase 12-like a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhrs12laprovided by ZNC
Official Full Name: dehydrogenase/reductase 12-like aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8104
See related: Ensembl:ENSDARG00000010764 AllianceGenome:ZFIN:ZDB-GENE-030131-8104
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: 36K; fj52f06; flj13639; wu:fj52f06; wu:fq25e07; zgc:136710
Summary: Acts upstream of or within with a positive effect on positive regulation of oligodendrocyte differentiation. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human DHRS12 (dehydrogenase/reductase 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (43166487..43196744)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (43285509..43315766)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A major myelin protein in zebrafish, 36K, is identified as a member of the short-chain dehydrogenase/reductase superfamily; an expression pattern similar to other myelin genes is demonstrated.
Title: The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: DHRS-12_like_SDR_c-like domain-containing protein

Names: short chain dehydrogenase/reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203511.1 → NP_987120.1 DHRS-12_like_SDR_c-like domain-containing protein

See identical proteins and their annotated locations for NP_987120.1

Status: PREDICTED

Source sequence(s)

AY316533

UniProtKB/TrEMBL

Q6W2N6

Related

ENSDARP00000023671.6, ENSDART00000011737.9

Conserved Domains (2) summary

cd09808
Location:40 → 294

DHRS-12_like_SDR_c-like; human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs

COG1028
Location:37 → 273

FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]