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    ehd2b EH-domain containing 2b [ Danio rerio (zebrafish) ]

    Gene ID: 337401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ehd2bprovided by ZNC
    Official Full Name
    EH-domain containing 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9347
    See related
    Ensembl:ENSDARG00000040362 AllianceGenome:ZFIN:ZDB-GENE-030131-9347
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ehd2; fj66d02; zgc:77671; wu:fj66d02
    Summary
    Predicted to enable ATP binding activity; GTP binding activity; and calcium ion binding activity. Predicted to be involved in several processes, including cilium assembly; endocytic recycling; and protein localization to plasma membrane. Predicted to be located in endosome and membrane. Predicted to be active in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in cardiovascular system; epidermis; notochord; and pharyngeal arch. Orthologous to human EHD2 (EH domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ehd2b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44649804..44663244)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44656350..44669790)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene uncharacterized LOC137488335 Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, alpha b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness. Issler N, et al. J Am Soc Nephrol, 2022 Apr. PMID 35149593, Free PMC Article
    2. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Lu Q, et al. Nat Cell Biol, 2015 Mar. PMID 25686250, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EH domain-containing protein 2b
    Names
    EH-domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200063.1 → NP_956357.1  EH domain-containing protein 2b

      See identical proteins and their annotated locations for NP_956357.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063963
      UniProtKB/TrEMBL
      A0A8M1PGF1, Q6P3J7
      Related
      ENSDARP00000059062.3, ENSDART00000059063.4
      Conserved Domains (4) summary
      smart00027
      Location:443 → 536
      EH; Eps15 homology domain
      cd09913
      Location:58 → 298
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:453 → 517
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:22 → 54
      EHD_N; N-terminal EH-domain containing protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44649804..44663244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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