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    fth1a ferritin, heavy polypeptide 1a [ Danio rerio (zebrafish) ]

    Gene ID: 58108, updated on 22-Dec-2024

    Summary

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    Official Symbol
    fth1aprovided by ZNC
    Official Full Name
    ferritin, heavy polypeptide 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000831-2
    See related
    Ensembl:ENSDARG00000015551 AllianceGenome:ZFIN:ZDB-GENE-000831-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fth1; fb06g09; zeh1145; hm:zeh1145; wu:fb06g09; wu:fq18c10
    Summary
    Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to act upstream of or within intracellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Is expressed in blood; eye; liver; ovary; and testis. Human ortholog(s) of this gene implicated in hemochromatosis type 5 and neurodegeneration with brain iron accumulation. Orthologous to several human genes including FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fth1a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (12927944..12936708)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (12675210..12683988)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene gap junction protein delta 6 Neighboring gene SH3-domain GRB2-like 3a Neighboring gene serum amyloid A Neighboring gene ribosomal protein, large P2, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fingerprinting fecal DNA and mRNA as a non-invasive strategy to assess the impact of polychlorinated biphenyl 126 exposure on zebrafish. Liu M, et al. J Environ Sci (China), 2021 Aug. PMID 34210431
    2. Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. Badenetti L, et al. Int J Mol Sci, 2023 Apr 6. PMID 37047777, Free PMC Article
    3. Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Usenko CY, et al. Toxicol Appl Pharmacol, 2008 May 15. PMID 18299140, Free PMC Article
    4. Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney. Zhang J, et al. PLoS Genet, 2018 Sep. PMID 30248094, Free PMC Article
    5. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ferritin, heavy polypeptide 1a
    Names
    ferritin, heavy polypeptide 1
    NP_571660.1
    XP_017212392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131585.1 → NP_571660.1  ferritin, heavy polypeptide 1a

      See identical proteins and their annotated locations for NP_571660.1

      Status: PROVISIONAL

      Source sequence(s)
      AF295373
      UniProtKB/TrEMBL
      A0A2R8QQC1, F6NRQ8, Q9DDT0
      Related
      ENSDARP00000026092.5, ENSDART00000027329.8
      Conserved Domains (2) summary
      cd01056
      Location:11 → 170
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:14 → 155
      Ferritin; Ferritin-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      12927944..12936708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356903.3 → XP_017212392.1  ferritin, heavy polypeptide 1a isoform X1

      UniProtKB/TrEMBL
      A0A2R8QQC1, F6NRQ8, Q9DDT0
      Conserved Domains (2) summary
      cd01056
      Location:11 → 170
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:14 → 155
      Ferritin; Ferritin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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