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    zfyve19 zinc finger, FYVE domain containing 19 [ Danio rerio (zebrafish) ]

    Gene ID: 436685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfyve19provided by ZNC
    Official Full Name
    zinc finger, FYVE domain containing 19provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-109
    See related
    Ensembl:ENSDARG00000003642 AllianceGenome:ZFIN:ZDB-GENE-040718-109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92683
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission and mitotic cytokinesis checkpoint signaling. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See zfyve19 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2108902..2126657, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1933703..1949844, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type 1 a Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Bb Neighboring gene p21 (RAC1) activated kinase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    abscission/NoCut checkpoint regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002412.1 → NP_001002412.1  abscission/NoCut checkpoint regulator

      See identical proteins and their annotated locations for NP_001002412.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076167
      UniProtKB/TrEMBL
      Q6DH17
      Related
      ENSDARP00000002470.7, ENSDART00000013093.8
      Conserved Domains (2) summary
      PRK13890
      Location:101 → 177
      PRK13890; conjugal transfer protein TrbA; Provisional
      cd15749
      Location:4 → 54
      FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      2108902..2126657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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