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    mtf1 metal-regulatory transcription factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 195821, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mtf1provided by ZNC
    Official Full Name
    metal-regulatory transcription factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020424-1
    See related
    Ensembl:ENSDARG00000102898 AllianceGenome:ZFIN:ZDB-GENE-020424-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MTF-1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; female organism; heart; male organism; and spleen. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mtf1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4133864..4168891)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (3819099..4337174)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein DDB_G0271670 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene uncharacterized LOC100535213 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing Neighboring gene ribosomal RNA processing 15 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Dalton TP, et al. Comp Biochem Physiol B Biochem Mol Biol, 2000 Jul. PMID 11007174
    2. Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish. Hogstrand C, et al. Biochem Soc Trans, 2008 Dec. PMID 19021535
    3. Cytotoxicities and induction of metallothionein (MT) and metal regulatory element (MRE)-binding transcription factor-1 (MTF-1) messenger RNA levels in the zebrafish (Danio rerio) ZFL and SJD cell lines after exposure to various metal ions. Cheuk WK, et al. Aquat Toxicol, 2008 Aug 29. PMID 18639347
    4. Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium. Chen WY, et al. Environ Toxicol Chem, 2007 Jan. PMID 17269467
    5. Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride. Macirella R, et al. Int J Mol Sci, 2017 Apr 13. PMID 28406445, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The functional characterization of a complete zebrafish MTF-1, is reported.
      Title: Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development.
    2. MTF1 is a master regulator of gene expression during development.
      Title: Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to zinc ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metal regulatory transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152981.1 → NP_694513.1  metal regulatory transcription factor 1

      See identical proteins and their annotated locations for NP_694513.1

      Status: PROVISIONAL

      Source sequence(s)
      AF458116
      UniProtKB/TrEMBL
      Q8QGH4
      Related
      ENSDARP00000146080.1, ENSDART00000192403.1
      Conserved Domains (3) summary
      COG5048
      Location:140 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:245 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 282
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      4133864..4168891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466610.2 → XP_021322285.1  metal regulatory transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KFP7, A0A8M9PM66
      Related
      ENSDARP00000148642.1, ENSDART00000175718.2
      Conserved Domains (2) summary
      COG5048
      Location:185 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_021466611.2 → XP_021322286.1  metal regulatory transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A0B5H7U7, A0A8M9PJ79
      Related
      ENSDARP00000145940.1, ENSDART00000193036.1
      Conserved Domains (2) summary
      COG5048
      Location:140 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:245 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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