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    mdm2 MDM2 proto-oncogene [ Danio rerio (zebrafish) ]

    Gene ID: 30637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdm2provided by ZNC
    Official Full Name
    MDM2 proto-oncogeneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-153
    See related
    Ensembl:ENSDARG00000033443 AllianceGenome:ZFIN:ZDB-GENE-990415-153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu923; zgc:109834
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blood; digestive system; head; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mdm2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (23125750..23136127)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (23404700..23414304)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2a Neighboring gene uncharacterized LOC137491549 Neighboring gene solute carrier family 35 member E3 Neighboring gene thyrotropin releasing hormone degrading enzyme, tandem duplicate 1 Neighboring gene uncharacterized LOC137491550 Neighboring gene uncharacterized LOC137490087 Neighboring gene thyrotropin releasing hormone degrading enzyme, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Halobenzoquinone-Induced Developmental Toxicity, Oxidative Stress, and Apoptosis in Zebrafish Embryos. Wang C, et al. Environ Sci Technol, 2018 Sep 18. PMID 30125093
    2. The Mdm2 and p53 genes are conserved in the Arachnids. Lane DP, et al. Cell Cycle, 2010 Feb 15. PMID 20160485
    3. Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish. Chen LJ, et al. Dev Dyn, 2008 Apr. PMID 18297734
    4. Mdm2: keeping p53 under control. Piette J, et al. Oncogene, 1997 Aug 28. PMID 9285554
    5. Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes. Thomasova D, et al. J Am Soc Nephrol, 2015 Jul. PMID 25349197, Free PMC Article

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-seq analysis suggested important roles of Dhx15 in chromatin and nucleosome assembly and regulation of the Mdm2-p53 pathway.
      Title: Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.
    2. mutant Mdm2 was unable to rescue a p53-induced apoptotic phenotype.
      Title: Dysfunction of the MDM2/p53 axis is linked to premature aging.
    3. Data indicate that knockdown of the Mdm2 and Mdm4 caused dramatic accumulation of mutant p53 protein.
      Title: Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish.
    4. Data show that liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
      Title: Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109834, MGC113866, MGC192439

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pronephric glomerulus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of biological quality IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein stability IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Mdm2
    Names
    MDM2 oncogene, E3 ubiquitin protein ligase
    RING-type E3 ubiquitin transferase Mdm2
    double minute 2 protein
    etID309863.4
    murine double minute 2 homolog
    p53-binding protein Mdm2
    transformed 3T3 cell double minute 2 homolog
    NP_001352361.1
    NP_571439.3
    XP_005164901.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365432.1 → NP_001352361.1  E3 ubiquitin-protein ligase Mdm2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL929141
      UniProtKB/TrEMBL
      A0A0R4ISQ1, A0A8M2BC69, Q561Z0
      Related
      ENSDARP00000138060.2, ENSDART00000162859.2
      Conserved Domains (3) summary
      pfam00641
      Location:286 → 312
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:21 → 82
      SWIB; SWIB/MDM2 domain
      cd16783
      Location:430 → 486
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

    2. NM_131364.3 → NP_571439.3  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929141, AL935183
      UniProtKB/TrEMBL
      Q561Z0
      Related
      ENSDARP00000072320.4, ENSDART00000077854.6
      Conserved Domains (3) summary
      pfam00641
      Location:275 → 301
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:21 → 82
      SWIB; SWIB/MDM2 domain
      cd16783
      Location:419 → 475
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      23125750..23136127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164844.5 → XP_005164901.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

      See identical proteins and their annotated locations for XP_005164901.1

      UniProtKB/TrEMBL
      A0A0R4ISQ1, A0A8M2BC69, Q561Z0
      Conserved Domains (3) summary
      pfam00641
      Location:286 → 312
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:21 → 82
      SWIB; SWIB/MDM2 domain
      cd16783
      Location:430 → 486
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395231.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      301043..311289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42354.1 GenPept UniProtKB/Swiss-Prot:O42354

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