hspb8 heat shock protein b8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspb8provided by ZNC
Official Full Name: heat shock protein b8provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2480
See related: Ensembl:ENSDARG00000058365 AllianceGenome:ZFIN:ZDB-GENE-030131-2480
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc09c11; zgc:64202; wu:fc04b04; wu:fc09c11
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cephalic musculature; immature eye; midbrain hindbrain boundary neural rod; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (15819705..15839416)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (15319488..15339199)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Hspb8 in Zebrafish.
Title: Characterization of Hspb8 in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc09c11.x1 (e-PCR)
- UniSTS:187729

fc04b04.x1 (e-PCR)
- UniSTS:203691

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein folding chaperone complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein beta-8

Names: heat shock protein, alpha-crystallin-related, b8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100957.2 → NP_001094427.2 heat shock protein beta-8

See identical proteins and their annotated locations for NP_001094427.2

Status: PROVISIONAL

Source sequence(s)

BC057441

UniProtKB/TrEMBL

Q6PFS1

Related

ENSDARP00000149403.1, ENSDART00000186969.1

Conserved Domains (1) summary

cd06480
Location:88 → 178

ACD_HspB8_like; Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and ...