nipsnap1 nipsnap homolog 1 (C. elegans) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nipsnap1provided by ZNC
Official Full Name: nipsnap homolog 1 (C. elegans)provided by ZNC
Primary source: ZFIN:ZDB-GENE-991008-17
See related: Ensembl:ENSDARG00000005320 AllianceGenome:ZFIN:ZDB-GENE-991008-17
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153339
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including endoderm; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study Parkinson's disease. Orthologous to human NIPSNAP1 (nipsnap homolog 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (12032802..12063377, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (11532585..11563160, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIPSNAP1 and NIPSNAP2 act as ""eat me"" signals to allow sustained recruitment of autophagy receptors during mitophagy.
Title: NIPSNAP1 and NIPSNAP2 act as "eat me" signals to allow sustained recruitment of autophagy receptors during mitophagy.
NIPSNAP1 and NIPSNAP2 have a redundant function in mitophagy and are predominantly expressed in different tissues.
Title: NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein NipSnap homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.