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    dbr1 debranching RNA lariats 1 [ Danio rerio (zebrafish) ]

    Gene ID: 323746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dbr1provided by ZNC
    Official Full Name
    debranching RNA lariats 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2466
    See related
    Ensembl:ENSDARG00000056923 AllianceGenome:ZFIN:ZDB-GENE-030131-2466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63930; wu:fc08f08
    Summary
    Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dbr1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (27860336..27868266, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (28049590..28057520, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene rho-associated protein kinase 2-like Neighboring gene uncharacterized LOC137490686 Neighboring gene si:rp71-45g20.4 Neighboring gene armadillo repeat containing 8 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA lariat debranching enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lariat debranching enzyme
    Names
    debranching enzyme homolog 1
    NP_955947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199653.1 → NP_955947.1  lariat debranching enzyme

      See identical proteins and their annotated locations for NP_955947.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053153
      UniProtKB/Swiss-Prot
      Q7T3E4
      Related
      ENSDARP00000073957.4, ENSDART00000079502.5
      Conserved Domains (3) summary
      cd00844
      Location:3 → 263
      MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
      pfam00149
      Location:1 → 229
      Metallophos; Calcineurin-like phosphoesterase
      pfam05011
      Location:245 → 376
      DBR1; Lariat debranching enzyme, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      27860336..27868266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395282.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      527315..535245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3E4.1 GenPept UniProtKB/Swiss-Prot:Q7T3E4

    Gene LinkOut

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