ptges3a prostaglandin E synthase 3a (cytosolic) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptges3aprovided by ZNC
Official Full Name: prostaglandin E synthase 3a (cytosolic)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2200
See related: Ensembl:ENSDARG00000037284 AllianceGenome:ZFIN:ZDB-GENE-040426-2200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Tebp; ptges3; cPGES-1; zgc:65804; zgc:77131; wu:fb98d06
Summary: Predicted to enable Hsp90 protein binding activity; prostaglandin-E synthase activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including prostaglandin biosynthetic process; protein-containing complex assembly; and telomere maintenance via telomerase. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in digestive system; endoderm; hindbrain neural keel; nervous system; and pronephric duct. Orthologous to human PTGES3 (prostaglandin E synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (27051989..27059998)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (27125448..27133457)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish cytosolic (c) PGES-1 and COX-1 were coordinately expressed in the inner ear, the pronephros, and intestine.
Title: Prostaglandin E synthases in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomerase holoenzyme complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E synthase 3

Names: cytosolic prostaglandin E synthase; prostaglandin E synthase 3 (cytosolic); telomerase binding protein, p23

NP_998335.1

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213170.1 → NP_998335.1 prostaglandin E synthase 3

See identical proteins and their annotated locations for NP_998335.1

Status: PROVISIONAL

Source sequence(s)

BC065314

UniProtKB/TrEMBL

B2GRI0, F6NMY6, Q7SZQ8

Related

ENSDARP00000054236.6, ENSDART00000054237.7

Conserved Domains (1) summary

cl00175
Location:3 → 109

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.