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    myo9b myosin IXb [ Danio rerio (zebrafish) ]

    Gene ID: 560956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo9bprovided by ZNC
    Official Full Name
    myosin IXbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-938
    See related
    Ensembl:ENSDARG00000077410 AllianceGenome:ZFIN:ZDB-GENE-030131-938
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb53f01; wu:fb53f01; wu:fc47c07; si:dkeyp-66d1.8
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and actin filament binding activity. Predicted to be involved in actin filament-based movement and lamellipodium morphogenesis. Predicted to act upstream of or within intracellular signal transduction. Predicted to be part of myosin complex. Predicted to be active in actin filament; lamellipodium; and ruffle. Orthologous to human MYO9B (myosin IXB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See myo9b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37684922..37744992, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37702465..37762542, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene insulin receptor a Neighboring gene major facilitator superfamily domain containing 14A2 Neighboring gene myeloid associated differentiation marker b Neighboring gene finTRIM family, member 66

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. Lin-Jones J, et al. J Comp Neurol, 2009 Mar 10. PMID 19137585, Free PMC Article
    2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
    3. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that myo9b is localized in actin-rich ellipsoids of fish cones.
      Title: Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-IXb; unconventional myosin-IXb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37684922..37744992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351952.2 → XP_017207441.1  unconventional myosin-IXb isoform X3

      UniProtKB/TrEMBL
      A0A8M6YVZ6, E9QDU2
      Related
      ENSDARP00000112855.2, ENSDART00000144807.3

    2. XM_005171335.4 → XP_005171392.1  unconventional myosin-IXb isoform X4

      UniProtKB/TrEMBL
      A0A8M2BIN4
      Conserved Domains (5) summary
      smart00242
      Location:147 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:1470 → 1518
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:159 → 965
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:13 → 110
      UBQ; Ubiquitin-like proteins
      cl02570
      Location:1534 → 1719
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    3. XM_009298662.3 → XP_009296937.1  unconventional myosin-IXb isoform X2

      UniProtKB/TrEMBL
      A0A8M3APW7
      Conserved Domains (5) summary
      smart00242
      Location:147 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:1529 → 1577
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:159 → 965
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:13 → 110
      UBQ; Ubiquitin-like proteins
      cl02570
      Location:1593 → 1778
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. XM_005171334.5 → XP_005171391.1  unconventional myosin-IXb isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJ44, E7FFP7
      Related
      ENSDARP00000082473.5, ENSDART00000088040.6
      Conserved Domains (5) summary
      smart00242
      Location:147 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:1529 → 1577
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:159 → 965
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:13 → 110
      UBQ; Ubiquitin-like proteins
      cl02570
      Location:1593 → 1778
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    5. XM_009298664.4 → XP_009296939.1  unconventional myosin-IXb isoform X6

      UniProtKB/TrEMBL
      A0A8M3AQC3
      Conserved Domains (5) summary
      smart00242
      Location:147 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:1529 → 1577
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:159 → 965
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:13 → 110
      UBQ; Ubiquitin-like proteins
      cl02570
      Location:1593 → 1778
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    6. XM_009298663.4 → XP_009296938.1  unconventional myosin-IXb isoform X5

      UniProtKB/TrEMBL
      A0A8M3B7U1
      Conserved Domains (5) summary
      smart00242
      Location:147 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:1529 → 1577
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:159 → 965
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:13 → 110
      UBQ; Ubiquitin-like proteins
      cl02570
      Location:1593 → 1778
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein Strain
    Heading Accession and Version

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